1-chloro-3-methoxy-2-nitro-benzene

Base Information

• Chemical Name: 1-chloro-3-methoxy-2-nitro-benzene
• CAS No.: 5472-99-1
• Molecular Formula: C7H6 Cl N O3
• Molecular Weight: 187.583
• Hs Code.: 2909309090
• Mol file: 5472-99-1.mol

Synonyms:Anisole,3-chloro-2-nitro- (6CI); 1-Chloro-3-methoxy-2-nitrobenzene; NSC 29552

Chemical Property of 1-chloro-3-methoxy-2-nitro-benzene

Chemical Property:

• Vapor Pressure: 0.00325mmHg at 25°C
• Melting Point: 90 °C
• Boiling Point: 292.2°Cat760mmHg
• Flash Point: 130.5°C
• PSA: 55.05000
• Density: 1.366g/cm³
• LogP: 2.78000
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-Chloro-3-methoxy-2-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-chloro-3-methoxy-2-nitro-benzene

There total 11 articles about 1-chloro-3-methoxy-2-nitro-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3-methoxy-2-nitroaniline (16554-47-5) → 3-chloro-2-nitroanisole (5472-99-1)

Guidance literature:

3-methoxy-2-nitroaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With hydrogenchloride; copper dichloride; In water; at 0 - 20 ℃; for 48h;

Reference yield:

2,6-dichloronitrobenzene (601-88-7) + sodium methylate (124-41-4) → 3-chloro-2-nitroanisole (5472-99-1)

Guidance literature:

With methanol; Kinetik dieser Reaktion bei 85grad und 110grad;

Reference yield:

3-methoxy-2-nitrobenzoic acid (4920-80-3) → 3-chloro-2-nitroanisole (5472-99-1)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂

2: 1.) NaN₃, 2.) H₂O, 4.) NaOH, 5.) HCl

3: 1.) 98percent sulfuric acid, NaNO₂, 2.) CuCl₂, 36percent aq. HCl / 1.) acetic acid, 10 deg C, 1 h, 2.) acetic acid, RT, 1 h

With hydrogenchloride; sodium hydroxide; thionyl chloride; sodium azide; sulfuric acid; water; copper dichloride; sodium nitrite;

DOI:10.1021/jm00063a014

upstream raw materials:

methanol

2,6-dichloronitrobenzene

sodium methylate

4-methoxy-2,3-dinitro-aniline

Downstream raw materials:

2-methoxy-6-(methylthio)aniline

2-methoxy-6-(methylsulfonyl)aniline

2-nitro-3-(methylsulfonyl)anisole

1-(2-Chloro-6-hydroxy-phenyl)-3-pentyl-urea

Refernces

• 1、 -. "NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS". Page/Page column 139. . Retrieved 2008/06/13.