Cyclopropylmethyl phenyl ketone

Base Information

• Chemical Name: Cyclopropylmethyl phenyl ketone
• CAS No.: 6739-22-6
• Molecular Formula: C11H12O
• Molecular Weight: 160.216
• Hs Code.: 2914399090
• Mol file: 6739-22-6.mol

Synonyms:2-cyclopropyl-1-phenylethanone;

Chemical Property of Cyclopropylmethyl phenyl ketone

Chemical Property:

• Boiling Point: 253.536 °C at 760 mmHg
• Flash Point: 101.945 °C
• PSA: 17.07000
• Density: 1.066 g/cm³
• LogP: 2.66940

Purity/Quality:

99% ^*data from raw suppliers

2-cyclopropyl-1-phenylethan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropylmethyl phenyl ketone

There total 25 articles about Cyclopropylmethyl phenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-2-cyclopropyl-1-phenylethan-1-one (84040-29-9) → 2-cyclopropyl-1-phenylethanone (6739-22-6)

Guidance literature:

With benzoic acid; zinc; In acetonitrile; at 25 ℃; for 3.5h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/acs.joc.9b02026

Reference yield: 92.0%

cyclopropyl-2 dimethoxy-1,1 phenyl-1 ethane (89238-04-0) → 2-cyclopropyl-1-phenylethanone (6739-22-6)

Guidance literature:

With water; oxalic acid; silica gel; for 0.166667h;

DOI:10.1016/S0040-4020(01)91581-9

Reference yield: 90.0%

2-cyclopropylacetonitrile (6542-60-5) + phenylmagnesium bromide → 2-cyclopropyl-1-phenylethanone (6739-22-6)

Guidance literature:

DOI:10.1039/c39820001037

upstream raw materials:

cyclopropylmethyl iodide

phenyl(trimethylsiloxy)acetonitrile

2-cyclopropyl-1-phenyl-1-ethanol

2-cyclopropylacetonitrile

Downstream raw materials:

2-bromo-2-cyclopropyl-1-phenylethan-1-one

2-cyclopropyl-1,3-diphenyl-1,3-propanedione

Refernces

• 1、 Das, Sanju,De Sarkar, Suman,Mandal, Tanumoy. "Acridine Orange Hemi(Zinc Chloride) Salt as a Lewis Acid-Photoredox Hybrid Catalyst for the Generation of α-Carbonyl Radicals". supporting information. . Retrieved 2021/12/10.
• 2、 Sousa E Silva, Felipe Cesar,Doktor, Katarzyna,Michaudel, Quentin. "Modular Synthesis of Alkenyl Sulfamates and β-Ketosulfonamides via Sulfur(VI) Fluoride Exchange (SuFEx) Click Chemistry and Photomediated 1,3-Rearrangement". supporting information. p. 5271 - 5276. Retrieved 2021/07/20.