2,10-Dipropionyl-10H-phenothiazine

Base Information

• Chemical Name: 2,10-Dipropionyl-10H-phenothiazine
• CAS No.: 93963-98-5
• Molecular Formula: C18H17 N O2 S
• Molecular Weight: 311.404
• European Community (EC) Number: 300-844-2
• UNII: LP8DX43WPK
• DSSTox Substance ID: DTXSID30239982
• Nikkaji Number: J349.579E
• Wikidata: Q83122586
• Mol file: 93963-98-5.mol

Synonyms:2,10-Dipropionyl-10H-phenothiazine;93963-98-5;EINECS 300-844-2;1-(10-propanoylphenothiazin-2-yl)propan-1-one;1,1'-(10H-Phenothiazine-2,10-diyl)bis(propan-1-one);starbld0000701;LP8DX43WPK;Oprea1_375997;DTXSID30239982;Phenothiazine, 2,10-dipropionyl-;WS-02130;2,10-Bis(1-oxopropyl)-10H-phenothiazine;10H-Phenothiazine, 2,10-bis(1-oxopropyl)-;D85496

Chemical Property of 2,10-Dipropionyl-10H-phenothiazine

Chemical Property:

• Vapor Pressure: 3.12E-13mmHg at 25°C
• Boiling Point: 575.2°Cat760mmHg
• Flash Point: 301.7°C
• PSA: 62.68000
• Density: 1.233g/cm³
• LogP: 4.88360
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 311.09799996
• Heavy Atom Count: 22
• Complexity: 439

Purity/Quality:

98%Min ^*data from raw suppliers

2,10-DIPROPIONYL-10H-PHENOTHIAZINE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2C(=O)CC

Technology Process of 2,10-Dipropionyl-10H-phenothiazine

There total 2 articles about 2,10-Dipropionyl-10H-phenothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10H-phenothiazine (92-84-2) → 1-(10-propionyl-phenothiazin-2-yl)-propan-1-one (93963-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 2 h / Heating

2: AlCl₃ / CS₂ / 6 h / Heating

With aluminium trichloride; In carbon disulfide; toluene;

DOI:10.1021/jm960814j

Reference yield:

1-(10H-phenothiazin-10-yl)propan-1-one (6622-75-9) + propionyl chloride (79-03-8) → 1-(10-propionyl-phenothiazin-2-yl)-propan-1-one (93963-98-5)

Guidance literature:

With carbon disulfide; aluminium trichloride;

Reference yield:

1-(10-propionyl-phenothiazin-2-yl)-propan-1-one (93963-98-5) → Propionylpromazine (3568-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / ethanol

2: NaH

With hydrogenchloride; sodium hydride; In ethanol;

DOI:10.1021/jm960814j

upstream raw materials:

1-(10H-phenothiazin-10-yl)propan-1-one

propionyl chloride

10H-phenothiazine

Downstream raw materials:

2-propionylphenothiazine

Propionylpromazine

Refernces