Benzenepropanamine, a-methyl-N-(phenylmethyl)-

Base Information

• Chemical Name: Benzenepropanamine, a-methyl-N-(phenylmethyl)-
• CAS No.: 68164-04-5
• Molecular Formula: C17H21N
• Molecular Weight: 239.36
• Mol file: 68164-04-5.mol

Synonyms:

Chemical Property of Benzenepropanamine, a-methyl-N-(phenylmethyl)-

Chemical Property:

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanamine, a-methyl-N-(phenylmethyl)-

There total 11 articles about Benzenepropanamine, a-methyl-N-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-Phenyl-2-butanone (2550-26-7) + benzylamine (100-46-9) → N-benzyl-1-methyl-3-phenylpropylamine (68164-04-5)

Guidance literature:

With formic acid; 4-methoxy-N-(1-(naphthalen-2-yl)ethylidene)aniline; sodium formate; In water; at 80 ℃; for 24h; pH=4.8; Sealed tube; Inert atmosphere;

DOI:10.1002/chem.201204194

Reference yield: 97.0%

→ N-benzyl-1-methyl-3-phenylpropylamine (68164-04-5)

Guidance literature:

With formic acid; C₂₉H₃₂ClIrNO; sodium formate; In water; at 80 ℃; pH=4.8;

Reference yield: 88.0%

4-Phenyl-2-butanone (2550-26-7) + benzylamine hydrogenperchlorate (18720-46-2) → N-benzyl-1-methyl-3-phenylpropylamine (68164-04-5)

Guidance literature:

With tri-n-butyl-tin hydride; In N,N-dimethyl-formamide; at 20 ℃; for 7h;

upstream raw materials:

Benzyl-[1-methyl-3-phenyl-prop-(E)-ylidene]-amine

4-Phenyl-2-butanone

benzylamine

benzylamine hydrogenperchlorate

Downstream raw materials:

5-{2-[Benzyl-(1-methyl-3-phenyl-propyl)-amino]-acetyl}-2-methoxy-benzenesulfonamide

1-(4-ethoxycarbonylmethylphenoxy)-3-(1-methyl-3-phenylpropylamino)-2-propanol

N-benzyl-N-methyl-4-phenylbutan-2-amine

(S)-α-methylbenzenepropanamine hydrochloride

Refernces

• 1、 Kiyokawa, Kensuke,Jou, Keisuke,Minakata, Satoshi. "Intramolecular C?H Amination of N-Alkylsulfamides by tert-Butyl Hypoiodite or N-Iodosuccinimide". supporting information. p. 13971 - 13976. Retrieved 2021/08/30.
• 2、 Lei, Qian,Wei, Yawen,Talwar, Dinesh,Wang, Chao,Xue, Dong,Xiao, Jianliang. "Fast reductive amination by transfer hydrogenation "on water"". supporting information. p. 4021 - 4029. Retrieved 2013/04/10.