2-Piperidineethanol, 1-methyl-

Base Information

• Chemical Name: 2-Piperidineethanol, 1-methyl-
• CAS No.: 533-15-3
• Deprecated CAS: 107388-78-3
• Molecular Formula: C8H17NO
• Molecular Weight: 143.229
• Hs Code.: 2933 39 99
• European Community (EC) Number: 208-554-7
• NSC Number: 75616
• DSSTox Substance ID: DTXSID90862134
• Nikkaji Number: J188.374G
• Mol file: 533-15-3.mol

Synonyms:2-(1-methylpiperidin-2-yl)ethanol;533-15-3;2-Piperidineethanol, 1-methyl-;1-Methylpiperidine-2-ethanol;1-methyl-2-piperidineethanol;EINECS 208-554-7;NSC 75616;lobelol;SCHEMBL803674;DTXSID90862134;NSC75616;MFCD00673141;NSC-75616;STK499941;AKOS005171386;SB41849;2-(1-methylpiperidin-2-yl)ethan-1-ol;BB 0254416;FT-0671949;EN300-62687;2-(1-methylpiperidin-2-yl)ethanol, AldrichCPR;W-109554;Z139565496

Chemical Property of 2-Piperidineethanol, 1-methyl-

Chemical Property:

• Vapor Pressure: 0.0459mmHg at 25°C
• Refractive Index: 1.465
• Boiling Point: 209.7 °C at 760 mmHg
• PKA: 15.15±0.10(Predicted)
• Flash Point: 79.9 °C
• PSA: 23.47000
• Density: 0.938 g/cm³
• LogP: 0.79100
• Storage Temp.: Store below +30°C.
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 143.131014166
• Heavy Atom Count: 10
• Complexity: 95.3

Purity/Quality:

99.9% ^*data from raw suppliers

1-Methylpiperidine-2-ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCCCC1CCO
• Uses: Thioridazine intermediate. Thioridazine intermediate. Useful for preparing imidazolopyridines and imidazolopyrazines as SIK kinase inhibitors.

Technology Process of 2-Piperidineethanol, 1-methyl-

There total 8 articles about 2-Piperidineethanol, 1-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl iodide (74-88-4) → 2-(1-methyl-piperidin-2-yl)-ethanol (533-15-3)

Guidance literature:

With benzene; at 25 ℃;

Reference yield:

2(RS)-(2-hydroxyethyl)piperidine (1484-84-0) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 2-(1-methyl-piperidin-2-yl)-ethanol (533-15-3)

Guidance literature:

With formic acid; water; at 140 ℃; (+-)-2-<1-methyl-<2>piperidyl>-ethanol;

DOI:10.1021/ja01195a048

Reference yield:

2-(2-Hydroxyethyl)pyridine (103-74-2) + methyl bromide (74-83-9) → 2-(1-methyl-piperidin-2-yl)-ethanol (533-15-3)

Guidance literature:

With acetonitrile; (+-)-2-<1-methyl-<2>piperidyl>-ethanol; und Hydrieren des Reaktionsprodukts in Methanol an Platin;

DOI:10.1021/ja01212a058

upstream raw materials:

2(RS)-(2-hydroxyethyl)piperidine

formaldehyd

methyl bisulfate

2-(2-Hydroxyethyl)pyridine

Downstream raw materials:

thioridazine

2-(2-chloroethyl)-1-methylpiperidine

chloranil

2-(2-benzoyloxy-ethyl)-1-methyl-piperidine; hydrochloride