4-(PHENYLSULFONYL)ANILINE

Base Information

• Chemical Name: 4-(PHENYLSULFONYL)ANILINE
• CAS No.: 7019-01-4
• Molecular Formula: C12H11NO2S
• Molecular Weight: 233.291
• Hs Code.: 2921420090
• Mol file: 7019-01-4.mol

Synonyms:p-aminophenyl phenyl sulfone;Benzenamine, 4-(phenylsulfonyl)-;p-Phenylsulfonylaniline;4-Benzenesulfonyl-phenylamine;4-benzenesulphonyl-phenylamine;4-aminophenyl phenyl sulfone;4-Aminodiphenylsulfone;1-amino-4-phenylsulfonylbenzene;

Chemical Property of 4-(PHENYLSULFONYL)ANILINE

Chemical Property:

• Melting Point: 175-177oC
• PSA: 68.54000
• LogP: 3.76360
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

4-Phenylsulfonylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Phenylsulfonylaniline is used in the preparation of novel Flufenamic acid analogues as inhibitors of androgen receptor mediated transcription.

Technology Process of 4-(PHENYLSULFONYL)ANILINE

There total 43 articles about 4-(PHENYLSULFONYL)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-nitrophenyl phenyl sulfone (1146-39-0) → p-aminophenyl phenyl sulfone (7019-01-4)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; dichloromethane; at 20 ℃;

Reference yield: 85.0%

triethoxyphenylsilane (780-69-8) + p-aminoiodobenzene (540-37-4) → p-aminophenyl phenyl sulfone (7019-01-4)

Guidance literature:

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 1,4-diazabicyclo[2.2.2]octane-triethylenediamine-bis(sulfur dioxide); tetrabutyl ammonium fluoride; N,N`-dimethylethylenediamine; In acetonitrile; at 120 ℃; for 24h; Glovebox; Inert atmosphere;

DOI:10.1002/chem.202103371

Reference yield: 64.0%

p-aminoiodobenzene (540-37-4) + phenylboronic acid (98-80-6) → p-aminophenyl phenyl sulfone (7019-01-4)

Guidance literature:

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 4,4'-Dimethoxy-2,2'-bipyridin; 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; at 110 ℃; for 36h;

DOI:10.1039/C6SC05483H

upstream raw materials:

4-nitrophenyl phenyl sulfone

(4-benzenesulfonyl-phenyl)-carbamic acid ethyl ester

N-(4-(phenylsulfonyl)phenyl)acetamide

N-phenylbenzenesulfonamide

Downstream raw materials:

p-hydroxyphenyl p-tolyl sulfone

N-(4-(phenylsulfonyl)phenyl)acetamide

4-benzenesulfonyl-N-sulfinyl-aniline

(4-benzenesulfonyl-phenyl)-phenyl-diazene

Refernces

• 1、 Adenot, Aurélien,Anthore-Dalion, Lucile,Nicolas, Emmanuel,Berthet, Jean-Claude,Thuéry, Pierre,Cantat, Thibault. "A Copper(I)-Catalyzed Sulfonylative Hiyama Cross-Coupling". supporting information. p. 18047 - 18053. Retrieved 2021/11/16.
• 2、 Kim, Dae-Kwon,Um, Hyun-Suk,Park, Hoyoon,Kim, Seonwoo,Choi, Jin,Lee, Chulbom. "Silyloxymethanesulfinate as a sulfoxylate equivalent for the modular synthesis of sulfones and sulfonyl derivatives". . p. 13071 - 13078. Retrieved 2021/01/09.