2-Propenoic acid, 3-(1H-imidazol-4-yl)-, methyl ester, (2E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-(1H-imidazol-4-yl)-, methyl ester, (2E)-
• CAS No.: 70346-51-9
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.153
• Mol file: 70346-51-9.mol

Synonyms:(E)-urocanic acid methyl ester;methyl 3-(1H-imidazol-4-yl)propenoate;methyl 3-(1H-imidazol-4-yl)acrylate;methyl 3-(4-imidazolyl)-2-propenoate;methyl (E)-3-(1H-imidazol-4-yl)acrylate;urocanic acid methyl ester;

Chemical Property of 2-Propenoic acid, 3-(1H-imidazol-4-yl)-, methyl ester, (2E)-

Chemical Property:

• Melting Point: 233.5-234.5 °C
• Boiling Point: 373.4±17.0 °C(Predicted)
• PSA: 54.98000
• Density: 1.247±0.06 g/cm3(Predicted)
• LogP: 0.59590

Purity/Quality:

99% ^*data from raw suppliers

(E)-Methyl3-(1H-imidazol-4-yl)acrylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-(1H-imidazol-4-yl)-, methyl ester, (2E)-

There total 9 articles about 2-Propenoic acid, 3-(1H-imidazol-4-yl)-, methyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + (E)-3-(1H-imidazol-4-yl)propenoic acid (3465-72-3) → methyl (E)-3-(1H-imidazol-5-yl)prop-2-enoate (70346-51-9)

Guidance literature:

With sulfuric acid; sodium sulfate; for 30h; Heating;

DOI:10.1021/jo991630q

Reference yield: 98.0%

methanol (67-56-1) + urocanic Acid (3465-72-3) → (E)-methyl 3-(1H-imidazol-4-yl)acrylate (70346-51-9)

Guidance literature:

With sulfuric acid; for 24h; Heating;

DOI:10.1021/jm00010a003

Reference yield: 91.0%

urocanic Acid (3465-72-3) → [4-((1-H-imidazol-4-yl)-3-propylcarbonylamino)-2-phenylbenzoyl]methionine trifluoroacetate + (E)-methyl 3-(1H-imidazol-4-yl)acrylate (70346-51-9)

Guidance literature:

In methanol;

upstream raw materials:

trans-4-imidazoleacrylic acid methyl ester hydrochloride

methanol

urocanic Acid

urocanic acid

Downstream raw materials:

trans-1-trityl-4-imidazoleacrylic acid methyl ester

methyl trans-4,5-dimethyl-2-<1H-imidazol-4-yl>cyclohex-4-ene-1-carboxylate

methyl (E)-3-<1-(p-toluenesulfonyl)-1H-imidazol-4(5)-yl>propenoate

pyrrolo<1,2-c>imidazol-5-one

Refernces

• 1、 Sharipov,Pershin,Salikhov, Sh. M.,Valeev. "Eleuthesides and their analogs: XI. Final stage of the synthesis of sarcodictyin A analog with 14-methylcyclohex-12-ene ring A". . p. 721 - 726. Retrieved 2016.
• 2、 Ali, Wajid,Anjana, S. S.,Bhattacharya, Trisha,Chandrashekar, Hediyala B.,Goswami, Nupur,Guin, Srimanta,Maiti, Debabrata,Panda, Sanjib,Prakash, Gaurav,Saha, Argha,Sasmal, Sheuli,Sinha, Soumya Kumar. "Photoinduced Regioselective Olefination of Arenes at Proximal and Distal Sites". supporting information. p. 1929 - 1940. Retrieved 2022/02/01.
• 3、 Xu, Yi-xiang,Wang, Huan,Li, Xiao-kang,Dong, Sheng-nan,Liu, Wen-wen,Gong, Qi,Wang, Tian-duan-yi,Tang, Yun,Zhu, Jin,Li, Jian,Zhang, Hai-yan,Mao, Fei. "Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease". supporting information. p. 33 - 47. Retrieved 2017/11/28.