2,3,4,5-Tetrahydro-1,6-benzodioxocin

Base Information

• Chemical Name: 2,3,4,5-Tetrahydro-1,6-benzodioxocin
• CAS No.: 7124-91-6
• Molecular Formula: C10H12O2
• Molecular Weight: 164.20100
• Mol file: 7124-91-6.mol

Synonyms:2,3,4,5-Tetrahydro-1,6-benzodioxocin;1,6-Benzodioxocin,2,3,4,5-tetrahydro;2,3,4,5-Tetrahydro-benzo[b][1,4]dioxocin;Catechol-tetramethylenether;

Chemical Property of 2,3,4,5-Tetrahydro-1,6-benzodioxocin

Chemical Property:

• PSA: 18.46000
• LogP: 2.23800

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,4,5-Tetrahydro-1,6-benzodioxocin

There total 5 articles about 2,3,4,5-Tetrahydro-1,6-benzodioxocin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(4-bromo-butoxy)-phenol (16837-07-3) → 2,3,4,5-Tetrahydro-benzo[b][1,4]dioxocin (7124-91-6)

Guidance literature:

With potassium carbonate; In i-Amyl alcohol; for 3h; Heating;

DOI:10.1002/jhet.5570270212

Reference yield: 75.0%

1,4-dibromo-butane (110-52-1) + benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → 2,3,4,5-Tetrahydro-benzo[b][1,4]dioxocin (7124-91-6)

Guidance literature:

With sodium hydroxide; Aliquat 336; In water; for 1h; Heating;

DOI:10.1081/SCC-100000172

Reference yield:

Potassium; 2-(4-bromo-butoxy)-phenolate (76670-09-2) → 2-(but-3-en-1-yloxy)phenol (60965-08-4) + 2,3,4,5-Tetrahydro-benzo[b][1,4]dioxocin (7124-91-6)

Guidance literature:

With potassium hydroxide; In water; dimethyl sulfoxide; at 25 ℃;

DOI:10.1021/jo00170a020

upstream raw materials:

2-(4-bromo-butoxy)-phenol

Potassium; 2-(4-bromo-butoxy)-phenolate

1,4-dibromo-butane

benzene-1,2-diol

Downstream raw materials:

3-Piperidin-1-yl-1-(2,3,4,5-tetrahydro-benzo[b][1,4]dioxocin-8-yl)-propan-1-one; hydrochloride

3-Diethylamino-1-(2,3,4,5-tetrahydro-benzo[b][1,4]dioxocin-8-yl)-propan-1-one; hydrochloride

8-phenylacetyl-2,3,4,5-tetrahydro-1,6-benzodioxocine

Phenyl-(2,3,4,5-tetrahydro-benzo[b][1,4]dioxocin-8-yl)-methanone

Refernces

• 1、 Eynde,Mailleux. "Quaternary ammonium salt-assisted organic reactions in water: Alkylation of phenols". . p. 1 - 7. Retrieved 2007/10/03.
• 2、 Cort, Antonella Dalla,Illuminati, Gabriello,Mandolini, Luigi,Masci, Bernardo. "Ring-closure Reactions. Part 15. Solvent Effect on Cyclic Aralkyl Ether Formation by Intramolecular Williamson Synthesis". . p. 1774 - 1777. Retrieved 2007/10/02.