6-Hydroxy-1,4-benzodioxane 6-Acetate

Base Information

• Chemical Name: 6-Hydroxy-1,4-benzodioxane 6-Acetate
• CAS No.: 7159-14-0
• Molecular Formula: C10H10O4
• Molecular Weight: 194.187
• Mol file: 7159-14-0.mol

Synonyms:

Chemical Property of 6-Hydroxy-1,4-benzodioxane 6-Acetate

Chemical Property:

• Melting Point: 110-111 °C
• Boiling Point: 150-152 °C(Press: 6 Torr)
• PSA: 44.76000
• Density: 1.244±0.06 g/cm3(Predicted)
• LogP: 1.38310
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate

Purity/Quality:

97% ^*data from raw suppliers

6-Hydroxy-1,4-benzodioxane6-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Hydroxy-1,4-benzodioxane 6-Acetate (cas# 7159-14-0) is a compound useful in organic synthesis.

Technology Process of 6-Hydroxy-1,4-benzodioxane 6-Acetate

There total 3 articles about 6-Hydroxy-1,4-benzodioxane 6-Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1,4-benzodioxan-6-yl methyl ketone (2879-20-1) → 2,3-dihydro-1,4-benzodioxin-6-yl acetate (7159-14-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/jm970795t

Reference yield:

6-amino-3,4-benzodioxane (22013-33-8) → 2,3-dihydro-1,4-benzodioxin-6-yl acetate (7159-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaNO₂, H₂SO₄ / 1.) H₂O, 0 deg C, 2.) 80 deg C

2: 1.) NaOH / 1.) RT, 2 h, 2.) 1 h

With sodium hydroxide; sulfuric acid; sodium nitrite;

DOI:10.1016/0223-5234(90)90163-W

Reference yield:

dihydrobenzo[1,4]dioxin-6-ol (10288-72-9) + acetic anhydride (108-24-7) → 2,3-dihydro-1,4-benzodioxin-6-yl acetate (7159-14-0)

Guidance literature:

With sulfuric acid; benzene;

upstream raw materials:

dihydrobenzo[1,4]dioxin-6-ol

acetic anhydride

1,4-benzodioxan-6-yl methyl ketone

6-amino-3,4-benzodioxane

Downstream raw materials:

hydroxy-6 benzodioxinne-1,4

dihydrobenzo[1,4]dioxin-6-ol

Refernces

• 1、 Bourlot, Anne-Sophie,Sánchez, Isabel,Dureng, Georges,Guillaumet, Gérald,Massingham, Roy,Monteil, André,Winslow, Eileen,Pujol, M. Dolors,Mérour, Jean-Yves. "New substituted 1,4-benzoxazine derivatives with potential intracellular calcium activity". . p. 3142 - 3158. Retrieved 2007/10/03.
• 2、 Guillaumet, Gerald,Hretani, Mohamed,Coudert, Gerard,Averbeck, Dietrich,Averbeck, Simone. "Synthese et proprietes biologiques photoinduites de dioxinnocoumarines lineaires". . p. 45 - 51. Retrieved 2007/10/02.