Pro-Ser

Base Information

• Chemical Name: Pro-Ser
• CAS No.: 71835-80-8
• Molecular Formula: C8H14N2O4
• Molecular Weight: 202.21
• DSSTox Substance ID: DTXSID70428595
• Nikkaji Number: J1.158.502G
• Wikidata: Q27143819
• Metabolomics Workbench ID: 78951
• ChEMBL ID: CHEMBL209083
• Mol file: 71835-80-8.mol

Synonyms:Pro-Ser;prolyl-serine;prolylserine

Chemical Property of Pro-Ser

Chemical Property:

• PSA: 102.15000
• LogP: -0.53080
• Storage Temp.: -15°C
• XLogP3: -4.8
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 202.09535693
• Heavy Atom Count: 14
• Complexity: 231

Purity/Quality:

99% ^*data from raw suppliers

H-Pro-Ser-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(NC1)C(=O)NC(CO)C(=O)O
• Isomeric SMILES: C1C[C@H](NC1)C(=O)N[C@@H](CO)C(=O)O

Technology Process of Pro-Ser

There total 2 articles about Pro-Ser which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(1-benzyloxycarbonyl-L-prolyl)-L-serine (73912-83-1) → prolyl‐serine (71835-80-8)

Guidance literature:

With ethanol; palladium; Hydrogenation;

Reference yield:

(S)-benzyloxycarbonyl-proline acid chloride (61350-60-5,61350-62-7,89705-40-8,106709-50-6) → prolyl‐serine (71835-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous NaOH

2: palladium; aqueous ethanol / Hydrogenation

With sodium hydroxide; ethanol; palladium;

Reference yield:

prolyl‐serine (71835-80-8) → L-serin (56-45-1,83245-15-2) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7)

Guidance literature:

With d-(5′-CCGCCATGGAGTTGAAACAAGGAAC-3*5′-TTAAAAGCTTTTTTTGATTAAAGCTGCCA-3′); water; In aq. phosphate buffer; at 25 ℃; pH=7.5; Reagent/catalyst; Temperature; pH-value; Kinetics;

DOI:10.1016/j.bbapap.2014.11.003

upstream raw materials:

N-(1-benzyloxycarbonyl-L-prolyl)-L-serine

(S)-benzyloxycarbonyl-proline acid chloride

Downstream raw materials:

L-serin

L-proline