(3-Fluorophenyl)trimethylsilane

Base Information

• Chemical Name: (3-Fluorophenyl)trimethylsilane
• CAS No.: 7217-41-6
• Molecular Formula: C9H13FSi
• Molecular Weight: 168.286
• DSSTox Substance ID: DTXSID10375377
• Nikkaji Number: J753.942H
• Wikidata: Q82163908
• Mol file: 7217-41-6.mol

Synonyms:(3-fluorophenyl)trimethylsilane;7217-41-6;(3-fluorophenyl)-trimethylsilane;Silane, (3-fluorophenyl)trimethyl-;3-Fluorophenyltrimethylsilane;1-(Trimethylsilyl)-3-fluorobenzene;SCHEMBL10442984;DTXSID10375377;AKOS006343779

Chemical Property of (3-Fluorophenyl)trimethylsilane

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 168.07705511
• Heavy Atom Count: 11
• Complexity: 128

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)C1=CC=CC(=C1)F

Technology Process of (3-Fluorophenyl)trimethylsilane

There total 4 articles about (3-Fluorophenyl)trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Fluoro-1,4-bis-trimethylsilanyl-benzene (128254-27-3) → (3-fluorophenyl)trimethylsilane (7217-41-6)

Guidance literature:

With potassium fluoride; In water; N,N-dimethyl-formamide; at 100 ℃; for 18h;

DOI:10.1016/S0040-4020(01)81469-1

Reference yield: 70.0%

chloro-trimethyl-silane (75-77-4) + 3-chlorofluorobenzene (625-98-9) → (3-fluorophenyl)trimethylsilane (7217-41-6)

Guidance literature:

With magnesium; sodium iodide; In tetrahydrofuran; at 15 ℃; for 10h; Glovebox; Inert atmosphere;

Reference yield: 55.0%

chloro-trimethyl-silane (75-77-4) + 3-fluorobromobenzene (1073-06-9) → (3-fluorophenyl)trimethylsilane (7217-41-6)

Guidance literature:

3-fluorobromobenzene; With iodine; magnesium; In tetrahydrofuran; Inert atmosphere; Reflux;

chloro-trimethyl-silane; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol1019162

upstream raw materials:

2-Fluoro-1,4-bis-trimethylsilanyl-benzene

chloro-trimethyl-silane

3-fluorobromobenzene

3-chlorofluorobenzene

Downstream raw materials:

3-Fluor-1,4-dihydrotrimethylsilylbenzol

fluorobenzene

methane

trimethylsiloxide anion

Refernces

• 1、 Ozaki, Tomoya,Kaga, Atsushi,Saito, Hayate,Yorimitsu, Hideki. "Generation of Aryllithium Reagents from N -Arylpyrroles Using Lithium". . p. 3019 - 3028. Retrieved 2021/06/02.
• 2、 Yarwood, Thomas David,Waring, Anthony John,Coe, Paul Leslie. "Synthetic applications of fluorinated phenyllithiums: Preparation of fluorinated α-methylstyrenes, benzhydrols, benzophenones and aryltrimethylsilanes". . p. 113 - 119. Retrieved 2007/10/03.