1-Propanol, 3-azido-

Base Information

• Chemical Name: 1-Propanol, 3-azido-
• CAS No.: 72320-38-8
• Molecular Formula: C3H7N3O
• Molecular Weight: 101.108
• Hs Code.: 2929909090
• European Community (EC) Number: 804-177-2
• DSSTox Substance ID: DTXSID20451131
• Nikkaji Number: J695.102C
• Wikidata: Q82271007
• Mol file: 72320-38-8.mol

Synonyms:3-azido-1-propanol;1-azidopropan-3-ol;3-azidopropanol;1-Propanol,3-azido;3-azido-propan-1-ol;1,3-azidopropanol;

Chemical Property of 1-Propanol, 3-azido-

Chemical Property:

• Refractive Index: n20/D1.461
• Boiling Point: 64 °C(Press: 2 Torr)
• Flash Point: 87℃
• PSA: 69.98000
• Density: 1.095 g/mL at 25 °C
• LogP: 0.13186
• Storage Temp.: 2-8°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 101.058911855
• Heavy Atom Count: 7
• Complexity: 76.2

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Azidopropan-1-ol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CN=[N+]=[N-])CO
• Uses: 3-azidopropan-1-ol is a useful research chemical. Small chain azido-alcohol for click chemistry applications.
• Description: 3-Azido-alcohol is a synthetic building block for adding an azide group with a hydroxyl handle. The azide group can react with alkyne such as BCN, DBCO, Propargyl group via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Technology Process of 1-Propanol, 3-azido-

There total 11 articles about 1-Propanol, 3-azido- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-bromo-3-propanol (627-18-9) → 3-azidopropan-1-ol (72320-38-8)

Guidance literature:

With sodium azide; In water; at 60 ℃;

DOI:10.1021/acs.joc.0c01084

Reference yield: 99.0%

1-chloro-3-hydroxypropane (627-30-5) → 3-azidopropan-1-ol (72320-38-8)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 24h;

DOI:10.1021/jo980689e

Reference yield: 70.0%

3-hydroxypropyl methanesulfonate (24590-50-9) → 3-azidopropan-1-ol (72320-38-8)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 8h;

DOI:10.1080/00397911.2015.1033428

upstream raw materials:

1-bromo-3-propanol

acrolein

1-chloro-3-hydroxypropane

2-(3-azidopropoxy)tetrahydro-2H-pyran

Downstream raw materials:

2-(2,3-dimethoxy-phenyl)-5,6-dihydro-4H-[1,3]oxazine

toluenesulfonic acid 3-azidopropyl ester

3-azidopropyl 3-O-benzyl-4,6-O-benzylidene-2-deoxy-2-phthalimido-β-D-glucopyranoside

C₂₉H₃₅N₃O₉

Refernces

• 1、 Wu,Zhang,Zhou,Wu,Ballard,Tian,Wang,Niu,Huang. "Expanding the genetic code for site-specific labelling of tobacco mosaic virus coat protein and building biotin-functionalized virus-like particles". . p. 4007 - 4009. Retrieved 2014.
• 2、 Ricks, Tanei J.,Cassilly, Chelsi D.,Carr, Adam J.,Alves, Daiane S.,Alam, Shahrina,Tscherch, Kathrin,Yokley, Timothy W.,Workman, Cameron E.,Morrell-Falvey, Jennifer L.,Barrera, Francisco N.,Reynolds, Todd B.,Best, Michael D.. "Labeling of Phosphatidylinositol Lipid Products in Cells through Metabolic Engineering by Using a Clickable myo-Inositol Probe". . p. 172 - 180. Retrieved 2019.
• 3、 Zhao, Ziwei,Yao, Xuemei,Zhang, Zhe,Chen, Li,He, Chaoliang,Chen, Xuesi. "Boronic acid shell-crosslinked dextran-b-PLA micelles for acid-responsive drug delivery". . p. 1609 - 1618. Retrieved 2014.
• 4、 Rong, Lei,Liu, Li-Han,Chen, Si,Cheng, Han,Chen, Chang-Sheng,Li, Ze-Yong,Qin, Si-Yong,Zhang, Xian-Zheng. "A coumarin derivative as a fluorogenic glycoproteomic probe for biological imaging". . p. 667 - 669. Retrieved 2014.
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• 6、 Kolmakov, Kirill,Wurm, Christian A.,Meineke, Dirk N. H.,Goettfert, Fabian,Boyarskiy, Vadim P.,Belov, Vladimir N.,Hell, Stefan W.. "Polar red-emitting rhodamine dyes with reactive groups: Synthesis, photophysical properties, and two-color STED nanoscopy applications". . p. 146 - 157. Retrieved 2014.
• 7、 Castanheira, Edgar J.,Correia, Tiago R.,Rodrigues, Jo?o M.M.,Mano, Jo?o F.. "Novel biodegradable laminarin microparticles for biomedical applications". . p. 713 - 719. Retrieved 2020.
• 8、 El Habnouni, Sarah,Darcos, Vincent,Garric, Xavier,Lavigne, Jean-Philippe,Nottelet, Benjamin,Coudane, Jean. "Mild methodology for the versatile chemical modification of polylactide surfaces: Original combination of anionic and click chemistry for biomedical applications". . p. 3321 - 3330. Retrieved 2011.
• 9、 We?ling, Patrik,Trumm, Michael,Macerata, Elena,Ossola, Annalisa,Mossini, Eros,Gullo, Maria Chiara,Arduini, Arturo,Casnati, Alessandro,Mariani, Mario,Adam, Christian,Geist, Andreas,Panak, Petra J.. "Activation of the Aromatic Core of 3,3′-(Pyridine-2,6-diylbis(1 H-1,2,3-triazole-4,1-diyl))bis(propan-1-ol) - Effects on Extraction Performance, Stability Constants, and Basicity". . p. 14642 - 14651. Retrieved 2019.
• 10、 Nan, Yanxia,Zhao, Wenjie,Xu, Xinhua,Au, Chak-Tong,Qiu, Renhua. "Synthesis, characterization and applications of selenocysteine-responsive nanoprobe based on dinitrobenzene sulfonyl-modified poly(carbonate) micelles". . p. 69299 - 69306. Retrieved 2015.