Diisopropyl phenylphosphonate

Base Information

• Chemical Name: Diisopropyl phenylphosphonate
• CAS No.: 7237-16-3
• Molecular Formula: C12H19O3P
• Molecular Weight: 242.255
• European Community (EC) Number: 635-286-1
• Nikkaji Number: J465.434J
• Mol file: 7237-16-3.mol

Synonyms:diisopropyl phenylphosphonate;7237-16-3;SCHEMBL4193997;AKOS024339507;phenyl-phosphonic acid diisopropyl ester

Chemical Property of Diisopropyl phenylphosphonate

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 242.10718146
• Heavy Atom Count: 16
• Complexity: 231

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)OP(=O)(C1=CC=CC=C1)OC(C)C

Technology Process of Diisopropyl phenylphosphonate

There total 40 articles about Diisopropyl phenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

iodobenzene (591-50-4) + diisopropyl hydrogenphosphonate (1809-20-7) → diisopropyl phenylphosphonate (7237-16-3)

Guidance literature:

With potassium fluoride; [Pd(η(5)-C5H5)Fe(η(5)-C5H3-C(CH3)=N-C6H4-4-CH3)Cl(P(C6H5)3)]; tetrabutylammomium bromide; isopropyl alcohol; In water; for 16h; Inert atmosphere; Reflux; Green chemistry;

DOI:10.1039/c3gc00030c

Reference yield: 98.0%

diisopropyl hydrogenphosphonate (1809-20-7) + triphenylantimony(V) diacetate (1538-62-1,34716-94-4) → diisopropyl phenylphosphonate (7237-16-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 60 ℃; for 6h; Inert atmosphere;

DOI:10.1248/cpb.c14-00727

Reference yield: 98.0%

diisopropyl hydrogenphosphonate (1809-20-7) + diphenyliodonium tetrafluoroborate → diisopropyl phenylphosphonate (7237-16-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃;

DOI:10.1081/SCC-100106038

upstream raw materials:

P,P-dichlorophenylphosphine oxide

isopropyl alcohol

Dichlorophenylphosphine

diisopropyl acetylphosphonate

Downstream raw materials:

P,P'-diphenyl-P,P'-decane-1,10-diyl-bis-phosphinic acid diisopropyl ester

hexakis(dimethylphenylphosphonite)technetium(I)-tetraphenylborate

phenylphosphonate

isopropyl methyl phenylphosphonate

Refernces

• 1、 Li, Chun Jing. "Aryltrimethylammonium Tetrafluoroborates in Nickel-Catalyzed C–P Bond-Forming Reactions". . p. 954 - 960. Retrieved 2021/07/22.
• 2、 Hicks, Ian,McTague, Jonathan,Hapatsha, Tatiana,Teriak, Rania,Kaur, Parminder. "Cobalt catalyzed C-P bond formation by cross-coupling of boronic acids with P(O)H compounds in presence of zinc". . . Retrieved 2020/01/31.