1-chloro-1-chloro-acetyl-cyclopropane

Base Information

• Chemical Name: 1-chloro-1-chloro-acetyl-cyclopropane
• CAS No.: 73492-25-8
• Molecular Formula: C4H4Cl2O
• Molecular Weight: 138.981
• DSSTox Substance ID: DTXSID60449092
• Mol file: 73492-25-8.mol

Synonyms:Cyclopropanecarbonyl chloride,1-chloro;1-Chlor-cyclopropancarbonylchlorid;1-chloro-cyclopropanecarbonyl chloride;1-chlorocyclopropanecarboxylic acid chloride;1-chlorocyclopropanecarboxylic chloride;1-chlorocyclopropane-1-carboxylic acid chloride;

Chemical Property of 1-chloro-1-chloro-acetyl-cyclopropane

Chemical Property:

• Boiling Point: 148.4±23.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.43±0.1 g/cm3(Predicted)
• LogP: 1.52320
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 137.9639201
• Heavy Atom Count: 7
• Complexity: 106

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1(C(=O)Cl)Cl

Technology Process of 1-chloro-1-chloro-acetyl-cyclopropane

There total 3 articles about 1-chloro-1-chloro-acetyl-cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

cyclopropanecarboxylic acid chloride (4023-34-1) → 1-chlorocyclopropanecarboxylic acid chloride (73492-25-8)

Guidance literature:

With N-chloro-succinimide; at 135 ℃; for 1.5h;

DOI:10.1021/ja00250a032

Reference yield:

1-chlorocyclopropane-1-carboxylic acid (108817-35-2) → 1-chlorocyclopropanecarboxylic acid chloride (73492-25-8)

Guidance literature:

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

cyclopropanecarboxylic acid chloride (4023-34-1) → 1-chlorocyclopropanecarboxylic acid chloride (73492-25-8)

Guidance literature:

bei der Chlorierung;

upstream raw materials:

cyclopropanecarboxylic acid chloride

1-chlorocyclopropane-1-carboxylic acid

Downstream raw materials:

1-(1-chlorocyclopropyl)-2-(2-chlorophenyl)ethanone

4'-(isopropoxy)-3'-(trifluoromethyl)-1-chlorocyclopropanecarboxanilide

Refernces

• 1、 Deycard, S.,Hughes, L.,Lusztyk, J.,Ingold, K. U.. "Kinetics of Cyclopropyl Radical Reactions. 3. Study of Some 1-Substituted Cyclopropyl Radicals by EPR Spectroscopy. The Inversion Barrier for 1-Methylcyclopropyl". . p. 4954 - 4960. Retrieved 2007/10/02.