benzyl N-[1-hydrazinyl-1-oxo-6-(phenylmethoxycarbonylamino)hexan-2-yl]carbamate

Base Information

• Chemical Name: benzyl N-[1-hydrazinyl-1-oxo-6-(phenylmethoxycarbonylamino)hexan-2-yl]carbamate
• CAS No.: 74283-31-1
• Molecular Formula: C22H28N4O5
• Molecular Weight: 428.4815
• NSC Number: 88486
• DSSTox Substance ID: DTXSID30293307
• Mol file: 74283-31-1.mol

Synonyms:74283-31-1;NSC88486;DTXSID30293307;NSC-88486;dibenzyl (6-hydrazinyl-6-oxohexane-1,5-diyl)biscarbamate (non-preferred name)

Chemical Property of benzyl N-[1-hydrazinyl-1-oxo-6-(phenylmethoxycarbonylamino)hexan-2-yl]carbamate

Chemical Property:

• Vapor Pressure: 8.52E-20mmHg at 25°C
• Boiling Point: 706.3°Cat760mmHg
• Flash Point: 380.9°C
• Density: 1.225g/cm³
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 13
• Exact Mass: 428.20597001
• Heavy Atom Count: 31
• Complexity: 548

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NCCCCC(C(=O)NN)NC(=O)OCC2=CC=CC=C2

Technology Process of benzyl N-[1-hydrazinyl-1-oxo-6-(phenylmethoxycarbonylamino)hexan-2-yl]carbamate

There total 3 articles about benzyl N-[1-hydrazinyl-1-oxo-6-(phenylmethoxycarbonylamino)hexan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine (405-39-0) → di-Z-L-lysine hydrazide (74283-31-1)

Guidance literature:

With pyrocatechol phosphorochloridite; triethylamine; toluene; Erwaermen der Reaktionsloesung mit N₂H₄;

DOI:10.1021/ja01141a022

Reference yield:

→ N2,N6-bis-benzyloxycarbonyl-DL-lysine hydrazide (74283-31-1)

Guidance literature:

With ethanol; hydrazine hydrate;

DOI:10.1007/BF00899303

Reference yield:

Nε-Cbz-lysine (55592-84-2) → di-Z-L-lysine hydrazide (74283-31-1)

Guidance literature:

With ethanol; hydrazine hydrate;

DOI:10.1093/oxfordjournals.rpd.a006697

upstream raw materials:

N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine

Nε-Cbz-lysine

Downstream raw materials:

N^α.N^ε-bis-benzyloxycarbonyl-L-lysyl azide

N^α,N^ε-di-Z-L-lysyl-glycyl-N^ε-Z-L-lysine methyl ester

(S)-6-Benzyloxycarbonylamino-2-{2-[2-((S)-2,6-bis-benzyloxycarbonylamino-hexanoylamino)-acetylamino]-acetylamino}-hexanoic acid methyl ester

(S)-6-Benzyloxycarbonylamino-2-(2-{2-[2-((S)-2,6-bis-benzyloxycarbonylamino-hexanoylamino)-acetylamino]-acetylamino}-acetylamino)-hexanoic acid methyl ester