2-Deoxy-2-fluoro-L-fucose

Base Information

• Chemical Name: 2-Deoxy-2-fluoro-L-fucose
• CAS No.: 70763-62-1
• Molecular Formula: C6H11 F O4
• Molecular Weight: 166.15
• Hs Code.: 2940000080
• European Community (EC) Number: 828-050-6
• UNII: W39886N0ZG
• DSSTox Substance ID: DTXSID60991021
• Nikkaji Number: J3.490.103A
• Wikidata: Q72462155
• NCI Thesaurus Code: C131289
• Metabolomics Workbench ID: 155407
• ChEMBL ID: CHEMBL4297429
• Mol file: 70763-62-1.mol

Synonyms:2-deoxy-2-fluoro-L-fucose

Chemical Property of 2-Deoxy-2-fluoro-L-fucose

Chemical Property:

• Vapor Pressure: 1.44E-07mmHg at 25°C
• Boiling Point: 386.5°C at 760 mmHg
• PKA: 12.70±0.20(Predicted)
• Flash Point: 187.6°C
• Density: 1.335g/cm³
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 166.06413699
• Heavy Atom Count: 11
• Complexity: 130

Purity/Quality:

98%Min ^*data from raw suppliers

2-Deoxy-2-fluoro-L-fucose ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C(C(C(C=O)F)O)O)O
• Isomeric SMILES: C[C@@H]([C@H]([C@H]([C@@H](C=O)F)O)O)O
• Uses: Fucose is a deoxyhexose that is present in many organisms. Fucose-containing glycans, generated by fucosyltransferase using GDP-fucose, have roles in cell signaling, cell-cell interactions, and blood properties. 2-deoxy-2-fluoro L-Fucose is a fluorinated fucose analog. It can be metabolized inside the cell to a substrate-based inhibitor of fucosyltransferases. Alternatively, it can be converted in vitro to GDP-2-deoxy-2-fluoro L-fucose, a competitive inhibitor of α1,3-fucosyltransferase V (Ki = 4.2 μM). 2-Deoxy-2-fluoro-L-fucose is a useful compound in the area of cancer treatment. as it has been used in adoptive cell therapy.