2-Butanone, 3-hydroxy-, (3S)-

Base Information

• Chemical Name: 2-Butanone, 3-hydroxy-, (3S)-
• CAS No.: 78183-56-9
• Molecular Formula: C4H8O2
• Molecular Weight: 88.1063
• Mol file: 78183-56-9.mol

Synonyms:

Chemical Property of 2-Butanone, 3-hydroxy-, (3S)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Butanone, 3-hydroxy-, (3S)-

There total 28 articles about 2-Butanone, 3-hydroxy-, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

sodium pyruvate (113-24-6) + acetaldehyde (75-07-0,9002-91-9) → (S)-acetoin (78183-56-9,51555-24-9)

Guidance literature:

With thiamine diphosphate; In phosphate buffer; at 25 ℃; pH=7.0;

DOI:10.1016/j.bioorg.2006.09.006

Reference yield: 60.0%

2-((S)-1-hydroxyethyl)-2-methyl-1,3-dithiane (101396-19-4) → (S)-acetoin (78183-56-9,51555-24-9)

Guidance literature:

With calcium carbonate; methyl iodide; In acetone; for 24h; Heating;

Reference yield: 50.0%

dimethylglyoxal (431-03-8) → (2R,3S)-2,3-butanediol (1029272-42-1) + (R,R)-2,3-butandiol (24347-58-8) + (S)-acetoin (78183-56-9,51555-24-9) + (R)-acetoin (53584-56-8,51555-24-9)

Guidance literature:

With hydrogen; Pt/Al₂O₃; cinchonine; In toluene; for 1.91667h; under 80256.4 Torr; Yield given. Further byproducts given. Title compound not separated from byproducts;

DOI:10.1039/a801390j

upstream raw materials:

(2R,3S)-2,3-butanediol

acetaldehyde

2-oxo-propionic acid

3-hydroxy-2-butanon

Downstream raw materials:

(2S,3S)-butane-2,3-diol

(2R,3S)-2,3-butanediol

C₇H₉NO₃

(-)-S-3-<oxy>-2-butanone

Refernces

• 1、 Li, Jian-Xiu,Huang, Yan-Yan,Chen, Xian-Rui,Du, Qi-Shi,Meng, Jian-Zong,Xie, Neng-Zhong,Huang, Ri-Bo. "Enhanced production of optical (: S)-acetoin by a recombinant Escherichia coli whole-cell biocatalyst with NADH regeneration". . p. 30512 - 30519. Retrieved 2018/09/11.
• 2、 Margitfalvi, József L.,Tálas, Emília. "Enantioselective hydrogenation of activated ketones in the presence of Pt-cinchona catalysts. Is the proton transfer concept valid?". . p. 142 - 145. Retrieved 2014/01/17.