3,4-DiMethoxy-1,2,5-thiadiazole 1-oxide

Base Information

• Chemical Name: 3,4-DiMethoxy-1,2,5-thiadiazole 1-oxide
• CAS No.: 78441-23-3
• Molecular Formula: C4H6N2O3S
• Molecular Weight: 162.169
• Hs Code.: 2934999090
• Mol file: 78441-23-3.mol

Synonyms:3,4-dimethoxy-1,2,5-thiadiazole monooxide;3,4-Dimethoxy-1,2,5-thiadiazole 1-oxide;

Chemical Property of 3,4-DiMethoxy-1,2,5-thiadiazole 1-oxide

Chemical Property:

• Melting Point: 135-137 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 232.1±23.0 °C(Predicted)
• PKA: -2.34±0.20(Predicted)
• PSA: 88.81000
• Density: 1.65±0.1 g/cm3(Predicted)
• LogP: 0.86490

Purity/Quality:

99%, ^*data from raw suppliers

95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-DiMethoxy-1,2,5-thiadiazole 1-oxide

There total 5 articles about 3,4-DiMethoxy-1,2,5-thiadiazole 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

oxaldiimidic acid dimethyl ester (30986-09-5) → 3,4-dimethoxy-1,2,5-thiadiazole-1-oxide (78441-23-3)

Guidance literature:

With pyridine; thionyl chloride;

DOI:10.1021/jm00345a003

Reference yield: 87.0%

3,4-dimethoxy-1,2,5-thiadiazole (55904-37-5) → 3,4-dimethoxy-1,2,5-thiadiazole-1-oxide (78441-23-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00345a003

Reference yield:

diethyl oximidate (13534-15-1,88770-07-4) → 3,4-dimethoxy-1,2,5-thiadiazole-1-oxide (78441-23-3)

Guidance literature:

With pyridine; thionyl chloride; In dichloromethane;

upstream raw materials:

methanol

3,4-Diethyloxy-1-oxo-1,2,5-thiadiazole

oxaldiimidic acid dimethyl ester

3,4-dimethoxy-1,2,5-thiadiazole

Downstream raw materials:

3-Amino-4-[3-(3-piperidinomethylphenoxy)propylamino]-1,2,5-thiadiazole 1-oxide

3-{2-[(5-dimethylaminomethyl-furan-2-yl)methylthio]ethylamino}-4-amino-1,2,5-thiadiazole 1-oxide

3-[3-(N-phenyl-N-2-pyridylamino)propylamino]-4-(4-pyridylmethyl)amino-1,2,5-thiadiazole-1-oxide

4-(p-fluorobenzylamino)-3-[3-(5-bromo-3-methylpyrid-2-ylamino)propylamino]-1,2,5-thiadiazole-1-oxide

Refernces

• 1、 -. "ANTIMIGRAINE 1,2,5-THIADIAZOLE DERIVATIVES OF INDOLYLALKYL-PYRIDNYL AND PYRIMIDINYLPIPERAZINES". . . Retrieved 2008/06/13.
• 2、 Algieri, Aldo A.,Luke, George M.,Standridge, Robert T.,Brown, Myron,Partyka, Richard A.,Crenshaw, R. R.. "1,2,5-Thiadizole 1-Oxide and 1,1-Dioxide Derivatives. A New Class of Potent Histamine H2-Receptor Antagoninists". . p. 210 - 212. Retrieved 2007/10/02.