Urea, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-[3-(trifluoro methyl)phenyl]-

Base Information

• Chemical Name: Urea, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-[3-(trifluoro methyl)phenyl]-
• CAS No.: 796967-48-1
• Molecular Formula: C20H22BF3N2O3
• Molecular Weight: 406.212
• Mol file: 796967-48-1.mol

Synonyms:

Chemical Property of Urea, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-[3-(trifluoro methyl)phenyl]-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Urea, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-[3-(trifluoro methyl)phenyl]-

There total 8 articles about Urea, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-[3-(trifluoro methyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-isocyanato-3-trifluoromethyl-benzene (329-01-1) + 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline (214360-73-3) → N-[4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]-N'-(3-trifluoromethylphenyl)urea (796967-48-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

Reference yield: 89.0%

→ N-[4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]-N'-(3-trifluoromethylphenyl)urea (796967-48-1)

Guidance literature:

Reference yield: 63.7%

bis(trichloromethyl) carbonate (32315-10-9) + 3-trifluoromethylaniline (98-16-8) + 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline (214360-73-3) → N-[4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]-N'-(3-trifluoromethylphenyl)urea (796967-48-1)

Guidance literature:

bis(trichloromethyl) carbonate; 3-trifluoromethylaniline; In dichloromethane; for 0.25h; Cooling with ice;

With triethylamine; In dichloromethane; for 0.25h;

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline; In dichloromethane; for 0.333333h;

upstream raw materials:

1-isocyanato-3-trifluoromethyl-benzene

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

3-trifluoromethylaniline

4-bromo-aniline

Downstream raw materials:

C₂₁H₁₅F₃N₄OS

Refernces

• 1、 Li, Chuansheng,Shan, Yuanyuan,Sun, Ying,Si, Ru,Liang, Liyuan,Pan, Xiaoyan,Wang, Binghe,Zhang, Jie. "Discovery of novel anti-angiogenesis agents. Part 7: Multitarget inhibitors of VEGFR-2, TIE-2 and EphB4". . p. 506 - 518. Retrieved 2017/11/14.
• 2、 -. "COMBINED MODULATION OF IRE1". Paragraph 0288. . Retrieved 2016/01/25.