(S)-(-)-LACTAMIDE

Base Information

• Chemical Name: (S)-(-)-LACTAMIDE
• CAS No.: 89673-71-2
• Molecular Formula: C₃H₇NO₂
• Molecular Weight: 89.0941
• Hs Code.: 2924 19 00
• Mol file: 89673-71-2.mol

Synonyms:Propanamide, 2-hydroxy-, (S)-; (-)-Lactamide;(S)-Lactamide

Chemical Property of (S)-(-)-LACTAMIDE

Chemical Property:

• Vapor Pressure: 0.000409mmHg at 25°C
• Melting Point: 53-55 °C(lit.)
• Refractive Index: 1.4368 (estimate)
• Boiling Point: 281.9°C at 760 mmHg
• PKA: 13.34±0.20(Predicted)
• Flash Point: 124.3°C
• PSA: 63.32000
• Density: 1.161g/cm³
• LogP: -0.44720
• Storage Temp.: Store below +30°C.
• Solubility.: 782g/l (experimental)

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-2-Hydroxypropanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: (S)-2-Hydroxypropanamide is a useful research reagent in the preparation of the antimicrobial natural product lipoxazolidinone A.

Technology Process of (S)-(-)-LACTAMIDE

There total 21 articles about (S)-(-)-LACTAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-hydroxy-propionitrile (78-97-7) → (+/-)-lactamide (598-81-2,2043-43-8,65144-02-7,89673-71-2)

Guidance literature:

With silver trifluoromethanesulfonate; C₃₃H₃₃ClO₇P₃Pt⁽¹⁺⁾*CF₃O₃S^(1-); In tetrahydrofuran; water; at 40 ℃; Catalytic behavior;

DOI:10.1021/acscatal.1c02254

Reference yield: 93.0%

→ (+/-)-lactamide (598-81-2,2043-43-8,65144-02-7,89673-71-2)

Guidance literature:

With silver tetrafluoroborate; C₃₆H₃₅ClFeOP₃Pt⁽¹⁺⁾*BF₄^(1-); In tetrahydrofuran; water; at 40 ℃; for 12h;

Reference yield: 90.0%

methyl lactate (547-64-8,2155-30-8) → (+/-)-lactamide (598-81-2,2043-43-8,65144-02-7,89673-71-2)

Guidance literature:

With ammonia; In methanol; Cooling with ice;

DOI:10.1246/cl.161006

upstream raw materials:

ethyl 2-hydroxypropionate

2-(2-hydroxy-1-oxopropoxy)propionic acid

2-hydroxy-propionitrile

O-acetyl-lactic acid acetylamide

Downstream raw materials:

lactic acid hydroxymethylamide

2-n-Hexyl-5-methyl-oxazol

p-Lactophenetide

acrylonitrile

Refernces

• 1、 -. "Catalyst, preparation method thereof and preparation method of amide compound". Paragraph 0142-0146; 0147. . Retrieved 2020/01/12.
• 2、 Xie, Zhenbing,Chen, Bingfeng,Peng, Fangfang,Liu, Mingyang,Liu, Huizhen,Yang, Guanying,Han, Buxing. "Highly Efficient Synthesis of Amino Acids by Amination of Bio-Derived Hydroxy Acids with Ammonia over Ru Supported on N-Doped Carbon Nanotubes". . p. 5683 - 5689. Retrieved 2020/09/21.