4-(TRIFLUOROMETHOXY)BENZAMIDE

Base Information

• Chemical Name: 4-(TRIFLUOROMETHOXY)BENZAMIDE
• CAS No.: 456-71-3
• Molecular Formula: C8H6F3NO2
• Molecular Weight: 205.136
• Hs Code.: 2924299090
• Mol file: 456-71-3.mol

Synonyms:p-Anisamide,a,a,a-trifluoro- (6CI,8CI);

Chemical Property of 4-(TRIFLUOROMETHOXY)BENZAMIDE

Chemical Property:

• Vapor Pressure: 0.026mmHg at 25°C
• Melting Point: 155-156 °C
• Refractive Index: 1.481
• Boiling Point: 247.2 °C at 760 mmHg
• PKA: 15.56±0.50(Predicted)
• Flash Point: 103.3 °C
• PSA: 52.32000
• Density: 1.381 g/cm³
• LogP: 2.38440

Purity/Quality:

98%min ^*data from raw suppliers

4-(Trifluoromethoxy)benzamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(Trifluoromethoxy)benzamide (CAS# 456-71-3) can be prepared to be used as an allosteric modulator of α7 nicotinic acetylcholine receptor. It can also be used for various antibacterial properties.

Technology Process of 4-(TRIFLUOROMETHOXY)BENZAMIDE

There total 21 articles about 4-(TRIFLUOROMETHOXY)BENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-trifluoromethoxybenzyl alcohol (1736-74-9) → 4-trifluoromethoxybenzamide (456-71-3)

Guidance literature:

With tert.-butylhydroperoxide; ammonia; oxygen; In water; N,N-dimethyl-formamide; at 80 ℃; for 5h; under 1520.1 Torr; Green chemistry;

DOI:10.1039/c4nj01457j

Reference yield: 95.5%

4-trifluoromethoxybenzyl alcohol (1736-74-9) → 4-(trifluoromethoxy)benzonitrile (332-25-2) + 4-trifluoromethoxybenzamide (456-71-3)

Guidance literature:

With ammonia; oxygen; In tert-Amyl alcohol; water; at 100 ℃; for 4h; under 3750.38 Torr; Overall yield = > 99 percent; Autoclave; High pressure;

DOI:10.1021/acscatal.0c00485

Reference yield: 95.0%

N-hydroxy-1-[4-(trifluoromethoxy)phenyl]methaneimine (150162-39-3) → 4-trifluoromethoxybenzamide (456-71-3)

Guidance literature:

With toluene-4-sulfonic acid; 1,2-bis-(diphenylphosphino)ethane; carbonyl(dihydro)tris(triphenylphosphine)ruthenium(II); In toluene; Heating;

DOI:10.1021/ol701445n

upstream raw materials:

4-(trifluoromethoxy)benzonitrile

4-(trifluoromethoxy)benzoyl fluoride

4-(trifluoromethoxy)benzoyl chloride

N-hydroxy-1-[4-(trifluoromethoxy)phenyl]methaneimine

Downstream raw materials:

N-benzyl-4-(trifluoromethoxy)benzamide

Refernces

• 1、 Cendón, Borja,Gulías, Moisés,Ho, Michelle,No?l, Timothy,Nyuchev, Alexander V.,Sambiagio, Carlo,Struijs, Job J. C.,Wan, Ting,Wang, Ying. "Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow". supporting information. p. 1305 - 1312. Retrieved 2020/07/10.
• 2、 Gates, Bruce C.,Guan, Erjia,Meng, Xiangju,Wang, Chengtao,Wang, Hai,Wang, Liang,Wang, Sai,Xiao, Feng-Shou,Xu, Dongyang,Xu, Hua,Yang, Bo,Zhang, Jian. "Atomically Dispersed Ru on Manganese Oxide Catalyst Boosts Oxidative Cyanation". . p. 6299 - 6308. Retrieved 2020/07/21.