1,3-Dibromo-5-chlorobenzene

Base Information

• Chemical Name: 1,3-Dibromo-5-chlorobenzene
• CAS No.: 14862-52-3
• Molecular Formula: C6H3Br2Cl
• Molecular Weight: 270.351
• Hs Code.: 29039990
• Mol file: 14862-52-3.mol

Synonyms:3,5-Dibromochlorobenzene;1-Chloro-3,5-dibromobenzene;

Chemical Property of 1,3-Dibromo-5-chlorobenzene

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.0356mmHg at 25°C
• Melting Point: 91-94 °C(lit.)
• Refractive Index: 1.612
• Boiling Point: 249.8 °C at 760 mmHg
• Flash Point: 115.8 °C
• PSA: 0.00000
• Density: 2.021 g/cm³
• LogP: 3.86500
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Toluene

Purity/Quality:

99% ^*data from raw suppliers

1,3-Dibromo-5-chlorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 1,3-Dibromo-5-chlorobenzene is a reactant in the preparation of orally bioavailable 1-(1H-indol-4-yl)-3,5-disubstituted benzene analogs as antimitotic agents.

Technology Process of 1,3-Dibromo-5-chlorobenzene

There total 8 articles about 1,3-Dibromo-5-chlorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,3,5-trisbromobenzene (626-39-1) → 1,3-dibromo-5-chlorobenzene (14862-52-3)

Guidance literature:

1,3,5-trisbromobenzene; With n-butyllithium; In hexanes; diethyl ether; at -78 ℃; for 0.333333h; Cooling with acetone-dry ice;

With hexachloroethane; In hexanes; diethyl ether; at -78 - 20 ℃; for 3.5h;

Reference yield:

3-Cl3SiC6H4SiCl3 (6838-76-2) → 1,3-dibromo-5-chlorobenzene (14862-52-3)

Guidance literature:

Multi-step reaction with 3 steps

1: HSiCl₃

2: Cl₂, FeCl₃

3: (i) MeMgBr, (ii) Br₂

With trichlorosilane; chlorine; iron(III) chloride;

Reference yield:

3-Cl3SiC6H4SiCl3 (6838-76-2) → 1,3-dibromo-5-chlorobenzene (14862-52-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Cl₂, FeCl₃

2: (i) MeMgBr, (ii) Br₂

With chlorine; iron(III) chloride;

upstream raw materials:

ethanol

3,5-dibromoaniline

4-chloro-2,6-dibromoaniline

5-Chlor-1.3-bis-trichlorsilyl-benzol

Downstream raw materials:

(3-bromo-5-chlorophenyl)(5-chloro-2-methoxyphenyl)methanone

3,3’-(5-chloro-1,3-phenylene)dipyridine

5-chloro-1,3-(2,2'-dipyridyl)benzene

1-[3,5-di(9H-carbazol-9-yl)phenyl]-2-phenylbenzimidazole

Refernces

• 1、 -. "BENZOPHENONES AS INHIBITORS OF REVERSE TRANSCRIPTASE". Page/Page column 23. . Retrieved 2010/11/08.