Benzeneacetic acid, a-methyl-, 3-hydroxypropyl ester

Base Information

• Chemical Name: Benzeneacetic acid, a-methyl-, 3-hydroxypropyl ester
• CAS No.: 80550-07-8
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Mol file: 80550-07-8.mol

Synonyms:2-Phenyl-propionic acid 3-hydroxy-propyl ester;3-hydoxypropyl-2-phenylpropanoate;

Chemical Property of Benzeneacetic acid, a-methyl-, 3-hydroxypropyl ester

Chemical Property:

• Boiling Point: 149 - 150 °C (2.3 mmHg)
• PSA: 46.53000
• Density: 1.095±0.06 g/cm3(Predicted)
• LogP: 1.71570

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, a-methyl-, 3-hydroxypropyl ester

There total 2 articles about Benzeneacetic acid, a-methyl-, 3-hydroxypropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-phenylpropanal trimethylene acetal (89539-08-2) → 3-hydroxypropyl 2-phenylpropanoate (80550-07-8)

Guidance literature:

With pyridinium perbromide hydrobromide; water; sodium acetate; In methanol; at 20 ℃; for 17h;

DOI:10.3987/COM-17-13682

Reference yield:

2-Phenylpropanal (34713-70-7) → 3-hydroxypropyl 2-phenylpropanoate (80550-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 84.4 percent / conc. H₂SO₄ / 0.25 h / Ambient temperature

2: 82.4 percent / 13 percent aq. sodium hypochlorite / acetic acid; acetone / 5 h / 0 °C

With sodium hypochlorite; sulfuric acid; In acetic acid; acetone;

upstream raw materials:

2-phenylpropanal trimethylene acetal

2-Phenylpropanal

Refernces

• 1、 Panchan, Waraporn,Chiampanichayakul, Supanimit,Snyder, Deanna L.,Yodbuntung, Siriporn,Pohmakotr, Manat,Reutrakul, Vichai,Jaipetch, Thaworn,Kuhakarn, Chutima. "Facile oxidative hydrolysis of acetals to esters using hypervalent iodine(III)/LiBr combination in water". experimental part. p. 2732 - 2735. Retrieved 2010/05/17.
• 2、 Sugai, Saburo,Kodama, Takashi,Akaboshi, Sanya,Ikegami, Shiro. "A Simple and Efficient Conversion of Aldehyde Acetals into Esters". . p. 99 - 105. Retrieved 2007/10/02.