Benzenemethanol, 4-hydroxy-, a-acetate

Base Information

• Chemical Name: Benzenemethanol, 4-hydroxy-, a-acetate
• CAS No.: 80767-12-0
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Mol file: 80767-12-0.mol

Synonyms:4-hydroxybenzyl acetate;4-Oxy-11-acetoxy-1-methyl-benzol;4-Acetoxymethyl-phenol;(4-Oxy-benzyl)-acetate;acetic acid 4-hydroxy-benzyl ester;4-acetoxymethylphenol;

Chemical Property of Benzenemethanol, 4-hydroxy-, a-acetate

Chemical Property:

• Melting Point: 50 °C
• Boiling Point: 272.2±15.0 °C(Predicted)
• PSA: 46.53000
• Density: 1.181±0.06 g/cm3(Predicted)
• LogP: 1.45530

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanol, 4-hydroxy-, a-acetate

There total 31 articles about Benzenemethanol, 4-hydroxy-, a-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

vinyl acetate (108-05-4,9003-20-7) + (4-hydroxyphenyl)methanol (623-05-2) → 4-hydroxybenzyl acetate (80767-12-0)

Guidance literature:

With Candida cylindracea lipase; In hexane; for 4h;

Reference yield: 100.0%

4-(acetyloxy)benzyl acetate (2937-64-6) → 4-hydroxybenzyl acetate (80767-12-0)

Guidance literature:

With Candida cylindracea lipase; In hexane; butan-1-ol; at 25 ℃; for 4h;

Reference yield: 98.0%

(4-hydroxyphenyl)methanol (623-05-2) + acetic acid (64-19-7,77671-22-8) → 4-hydroxybenzyl acetate (80767-12-0)

Guidance literature:

With 50wtpercent Cs_2.5H_0.5PW₁₂O₄₀ supported on MCM-41; In acetonitrile; at 50 ℃; for 0.5h;

DOI:10.1007/s12039-012-0291-8

upstream raw materials:

(4-hydroxyphenyl)methanol

acetic acid

vinyl acetate

4-(acetyloxy)benzyl acetate

Downstream raw materials:

4-hydroxybenzyl methyl ether

3-(4-hydroxyphenyl)-2-ethoxycarbonyl-propionic acid ethyl ester

2-(4-hydroxybenzyl)-2-methyl-1,3-cyclopentanedione

4-(4-Ethyl-phenoxymethyl)-phenol

Refernces

• 1、 -. "Gastrodin production process". Paragraph 0035-0040; 0043. . Retrieved 2017/01/17.
• 2、 Wang, Sasa,Chen, Xinzheng,Ao, Qiaoqiao,Wang, Huifei,Zhai, Hongbin. "Decarboxylative Csp3-Csp3 coupling for benzylation of unstable ketone enolates: Synthesis of: P -(acylethyl)phenols". supporting information. p. 9454 - 9457. Retrieved 2016/07/29.