Methanesulfonic acid, trifluoro-, 3-(1-methylethyl)phenyl ester

Base Information

• Chemical Name: Methanesulfonic acid, trifluoro-, 3-(1-methylethyl)phenyl ester
• CAS No.: 80841-09-4
• Molecular Formula: C10H11F3O3S
• Molecular Weight: 268.257
• Mol file: 80841-09-4.mol

Synonyms:

Chemical Property of Methanesulfonic acid, trifluoro-, 3-(1-methylethyl)phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanesulfonic acid, trifluoro-, 3-(1-methylethyl)phenyl ester

There total 2 articles about Methanesulfonic acid, trifluoro-, 3-(1-methylethyl)phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trifluoromethylsulfonic anhydride (358-23-6) + 3-isopropylhydroxybenzene (618-45-1) → meta-isopropylphenol trifluoromethanesulfonate (80841-09-4)

Guidance literature:

With pyridine; In diethyl ether; at 0 - 20 ℃;

DOI:10.1021/ol062378t

Reference yield:

3-isopropylhydroxybenzene (618-45-1) → meta-isopropylphenol trifluoromethanesulfonate (80841-09-4)

Guidance literature:

With 2,3-Lutidine; dmap; trifluoromethanesulfonic acid anhydride; In dichloromethane;

Reference yield: 78.0%

tributyl(1-ethoxyvinyl)stannane (97674-02-7) + meta-isopropylphenol trifluoromethanesulfonate (80841-09-4) → 1-[3-(propan-2-yl)phenyl]ethan-1-one (40428-87-3)

Guidance literature:

With bis(triphenylphosphine)palladium(II)-chloride; In N,N-dimethyl-formamide; at 60 ℃; for 8h;

DOI:10.1021/ol026014m

upstream raw materials:

trifluoromethylsulfonic anhydride

3-isopropylhydroxybenzene

Downstream raw materials:

10-(m-isopropylphenyl)-phenoxazine-4,6-dimethyldicarboxylate

(E)-3-(3-isopropyl-phenyl)-acrylic acid methyl ester

methyl 3-isopropylcinnamate

1-[3-(propan-2-yl)phenyl]ethan-1-one

Refernces

• 1、 Sandgren, Veronica,Agback, Tatiana,Johansson, Per-Ola,Lindberg, Jimmy,Kvarnstr?m, Ingemar,Samuelsson, Bertil,Belda, Oscar,Dahlgren, Anders. "Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: Design, synthesis and X-ray crystal structures of enzyme inhibitor complexes". supporting information; scheme or table. p. 4377 - 4389. Retrieved 2012/08/28.
• 2、 Yin, Hang,Lee, Gui-In,Hyung, Soon Park,Payne, Gregory A.,Rodriguez, Johanna M.,Sebti, Said M.,Hamilton, Andrew D.. "Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction". . p. 2704 - 2707. Retrieved 2007/10/03.