2,5-DIIODO-1-METHYLIMIDAZOLE

Base Information

• Chemical Name: 2,5-DIIODO-1-METHYLIMIDAZOLE
• CAS No.: 86026-81-5
• Molecular Formula: C₄H₄I₂N₂
• Molecular Weight: 333.898
• Hs Code.: 2933290090
• Mol file: 86026-81-5.mol

Synonyms:1-Methyl-2,5-diiodoimidazole;2,5-Diiodo-1-methylimidazole; NSC 347489

Chemical Property of 2,5-DIIODO-1-METHYLIMIDAZOLE

Chemical Property:

• Vapor Pressure: 4.07E-05mmHg at 25°C
• Melting Point: 138-143ºC
• Boiling Point: 351.6 °C at 760 mmHg
• Flash Point: 166.4 °C
• PSA: 17.82000
• Density: 2.83 g/cm³
• LogP: 1.62930
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Light Sensitive

Purity/Quality:

98%min ^*data from raw suppliers

2,5-Diiodo-1-methyl-1H-imidazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is employed as intermediate for pharmaceutical.

Technology Process of 2,5-DIIODO-1-METHYLIMIDAZOLE

There total 2 articles about 2,5-DIIODO-1-METHYLIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

1-methyl-1H-imidazole (616-47-7) → 2-iodo-1-methyl-1H-imidazole (37067-95-1) + 2,5-diiodo-1-methyl-1H-imidazole (86026-81-5)

Guidance literature:

With 1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane; sodium t-butanolate; In toluene; at 20 ℃; for 3h;

DOI:10.1039/c7ob03081a

Reference yield:

1-methyl-1H-imidazole (616-47-7) → 2,5-diiodo-1-methyl-1H-imidazole (86026-81-5)

Guidance literature:

With n-butyllithium; iodine; Yield given. Multistep reaction; 1.) ether, -70 deg C, 2.) ether, hexane, -35 deg C,2 h;

Reference yield: 90.0%

2,5-diiodo-1-methyl-1H-imidazole (86026-81-5) → 5-iodo-1N-methyl imidazole (71759-88-1)

Guidance literature:

With n-butyllithium; In diethyl ether; at -70 ℃;

upstream raw materials:

1-methyl-1H-imidazole

Downstream raw materials:

5-iodo-1N-methyl imidazole

Refernces

• 1、 -. "Method for preparing halogenated (hetero) aromatic hydrocarbons". Paragraph 0039; 0040. . Retrieved 2018/03/24.
• 2、 Holden, Kenneth G,Mattson, Matthew N,Cha, Kyung Hoi,Rapoport, Henry. "Synthesis of chiral pilocarpine analogues via a C-8 ketone intermediate.". . p. 5913 - 5918. Retrieved 2007/10/03.