exo-8-Methyl-3-aMino-azabicyclo[3.2.1]octane

Base Information

• Chemical Name: exo-8-Methyl-3-aMino-azabicyclo[3.2.1]octane
• CAS No.: 81487-04-9
• Molecular Formula: C8H16N2
• Molecular Weight: 140.228
• Hs Code.: 2933990090
• Mol file: 81487-04-9.mol

Synonyms:EXO-8-METHYL-3-AMINO-AZABICYCLO[3.2.1]OCTANE;

Chemical Property of exo-8-Methyl-3-aMino-azabicyclo[3.2.1]octane

Chemical Property:

• PSA: 29.26000
• LogP: 1.20850

Purity/Quality:

98%,99%, ^*data from raw suppliers

(1R,3R,5S)-8-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of exo-8-Methyl-3-aMino-azabicyclo[3.2.1]octane

There total 13 articles about exo-8-Methyl-3-aMino-azabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C15H20N2 → 3-endo-tropanamine (87571-88-8) + exo-3-amino-8-methyl-8-azabicyclo[3,2,1]octane (81487-04-9)

Guidance literature:

With platinum(IV) oxide; hydrogen; In ethanol; under 760.051 Torr; Reagent/catalyst; Pressure;

DOI:10.1021/op025570t

Reference yield: 70.0%

tropinone oxime (1515-26-0,14587-46-3) → exo-3-amino-8-methyl-8-azabicyclo[3,2,1]octane (81487-04-9)

Guidance literature:

With propan-1-ol; sodium; for 1.5h; Heating;

DOI:10.1021/jm9707129

Reference yield:

3-tropinone oxime → exo-3-amino-8-methyl-8-azabicyclo[3,2,1]octane (81487-04-9)

Guidance literature:

With sodium; In pentan-1-ol;

DOI:10.1016/S0223-5234(97)86174-0

upstream raw materials:

tropinone oxime

N-methyl-3-α-(4-methoxybenzylideneamino)nortropane

N-methyl-3-α-(4-dimethylaminobenzylideneamino)nortropane

3-chloro-4-(chlorocarbonyl)-4,9-dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

Downstream raw materials:

salicylic acid tropane-3exo-ylamide

tropane-3exo-yl-carbamic acid ethyl ester

N-(8-methylnortropan-3-β-yl)-3,4,5-trimethoxybenzamide

C₃₁H₃₅ClN₂O₅

Refernces

• 1、 Zhang, Hu-Shan,Feng, Dong-Zhi,Chen, Li,Long, Ya-Qiu. "Discovery of novel (S)-α-phenyl-γ-amino butanamide containing CCR5 antagonists via functionality inversion approach". body text. p. 2219 - 2223. Retrieved 2010/07/05.
• 2、 Allegretti, Marcello,Anacardio, Roberto,Cesta, M. Candida,Curti, Roberto,Mantovanini, Marco,Nano, Giuseppe,Topai, Alessandra,Zampella, Giuseppe. "A practical synthesis of 7-azaindolylcarboxy-endo-tropanamide (DF 1012)". . p. 209 - 213. Retrieved 2013/09/05.