Mephentermine

Base Information

• Chemical Name: Mephentermine
• CAS No.: 100-92-5
• Molecular Formula: C11H17 N
• Molecular Weight: 163.263
• Hs Code.: 2921499090
• European Community (EC) Number: 202-901-6
• UNII: TEZ91L71V4
• DSSTox Substance ID: DTXSID4023256
• Nikkaji Number: J4.989A
• Wikipedia: Mephentermine
• Wikidata: Q6817800
• NCI Thesaurus Code: C66089
• Pharos Ligand ID: V91V6BZKU5LZ
• Metabolomics Workbench ID: 43521
• ChEMBL ID: CHEMBL1201234
• Mol file: 100-92-5.mol

Synonyms:Mephentermine;Mephentermine Sulfate;Mephentermine Sulfate (2:1);Sulfate, Mephentermine

Chemical Property of Mephentermine

Chemical Property:

• Vapor Pressure: 0.0697mmHg at 25°C
• Melting Point: <25 °C
• Refractive Index: n20D 1.5110
• Boiling Point: 229.4°Cat760mmHg
• PKA: pKa (30°) 10.35
• Flash Point: 90°C
• PSA: 12.03000
• Density: 0.903g/cm³
• LogP: 2.61800
• Solubility.: Dichloromethane; Ethyl Acetate; Methanol; DMSO
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 163.136099547
• Heavy Atom Count: 12
• Complexity: 123

Purity/Quality:

99%, ^*data from raw suppliers

Mephentermine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(CC1=CC=CC=C1)NC
• Uses: Adrenergic (vasoconstrictor). Mephentermine is an α-adrenergic agonist. Mephentermine is used as an antihypotensive.
• Therapeutic Function: Adrenergic (vasopressor)

Technology Process of Mephentermine

There total 10 articles about Mephentermine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-Chloro-1,1-dimethyl-2-phenyl-ethyl)-methyl-amine; hydrochloride → mephentermine (100-92-5)

Guidance literature:

With hydrogen; sodium acetate; nickel; In methanol;

Reference yield:

α-(1-amino-1-methylethyl)benzenemethanol (34405-42-0) → mephentermine (100-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous hydriodic acid; phosphorus

3: anschliessend mit wss. Aethanol

With phosphorus; hydrogen iodide;

DOI:10.1021/ja01183a019

Reference yield:

Phentermin (122-09-8) → mephentermine (100-92-5)

Guidance literature:

Multi-step reaction with 2 steps

2: anschliessend mit wss. Aethanol

DOI:10.1021/ja01183a019

upstream raw materials:

β-Hydroxymephentermin

N-(2-methyl-1-phenylpropan-2-yl)-1-phenylmethanimine

methyl iodide

oxethazaine

Downstream raw materials:

(2-cyclohexyl-1,1-dimethyl-ethyl)-methyl-amine

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N,4-dimethyl-N-(2-methyl-1-phenylpropan-2-yl)-1H-pyrazole-3-carboxamide

2-Hydroxy-cyclohexylimino-bis-

(2-chloro-ethylimino)-di-acetic acid bis-[(1,1-dimethyl-2-phenyl-ethyl)-methyl-amide]

Refernces

• 1、 -. "Stereoisomers with high affinity for adrenergic receptors". . . Retrieved 2008/06/13.
• 2、 Dell,Donik,Jacobi,Kamp. "In vitro stability and biotransformation of 3'-hydroxy-2-[N-methyl-N-(1,1-dimethyl-2-phenethyl)amino] acetophenone (TVX 960)". . p. 1138 - 1144. Retrieved 2007/10/02.