5-Ethoxy-2-hydroxybenzaldehyde

Base Information

• Chemical Name: 5-Ethoxy-2-hydroxybenzaldehyde
• CAS No.: 80832-54-8
• Molecular Formula: C9H10 O3
• Molecular Weight: 166.177
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID10397594
• Nikkaji Number: J141.622G
• Wikidata: Q82199081
• Mol file: 80832-54-8.mol

Synonyms:5-ethoxy-2-hydroxybenzaldehyde;80832-54-8;5-Ethoxy-2-hydroxy-benzaldehyde;Benzaldehyde,5-ethoxy-2-hydroxy-;5-ethoxysalicylic aldehyde;2-Hydroxy-5-ethoxybenzaldehyde;SCHEMBL5882874;DTXSID10397594;HXCVPMBZBRPZLX-UHFFFAOYSA-N;BBL023669;MFCD05039365;STL288987;AKOS000104101;NS-01332;CS-0374035;EN300-09859;Z56347093

Chemical Property of 5-Ethoxy-2-hydroxybenzaldehyde

Chemical Property:

• Vapor Pressure: 6.29E-22mmHg at 25°C
• Melting Point: 51.5°C
• Refractive Index: 1.5260 (estimate)
• Boiling Point: 742.7°C at 760 mmHg
• Flash Point: 403°C
• PSA: 46.53000
• Density: 1.265g/cm³
• LogP: 1.60340
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 166.062994177
• Heavy Atom Count: 12
• Complexity: 147

Purity/Quality:

98%min ^*data from raw suppliers

5-Ethoxy-2-hydroxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC(=C(C=C1)O)C=O

Technology Process of 5-Ethoxy-2-hydroxybenzaldehyde

There total 3 articles about 5-Ethoxy-2-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-Ethoxyphenol (622-62-8) → 5-ethoxy-2-hydroxy-benzaldehyde (80832-54-8)

Guidance literature:

4-Ethoxyphenol; With Tri-n-octylamine; SnCl₃^(1-); In toluene; at 20 ℃; for 0.5h;

formaldehyd; at 80 ℃; for 12h;

Reference yield:

chloroform (67-66-3,8013-54-5) + 4-Ethoxyphenol (622-62-8) → 5-ethoxy-2-hydroxy-benzaldehyde (80832-54-8)

Guidance literature:

With sodium hydroxide; water; at 60 ℃;

Reference yield:

4-Ethoxyphenol (622-62-8) + hexamethylenetetramine (100-97-0) → 5-ethoxy-2-hydroxy-benzaldehyde (80832-54-8)

Guidance literature:

in ein zuvor auf 165grad erhitztes Gemisch von Glycerin und Borsaeure bei 150grad und Behandeln des Reaktionsgemisches mit wss.H₂SO₄ bei 115grad;

upstream raw materials:

chloroform

4-Ethoxyphenol

hexamethylenetetramine

formaldehyd

Downstream raw materials:

2,5-dihydroxybenzoic acid.

C₁₈H₁₆O₄

C₁₇H₁₃BrO₃

Refernces

• 1、 Ansar,Al Akoum Ebrik,Mouhoub,Berthelot,Vaccher,Vaccher,Flouquet,Caignard,Renard,Pirard,Rettori,Evrard,Durant,Debaert. "3-Benzo[b]furyl- and 3-benzo[b]thienylaminobutyric acids as GABA(B) ligands. Synthesis and structure-activity relationship studies". . p. 449 - 460. Retrieved 2007/10/03.