Technology Process of Benzenamine, N,N-dimethyl-4-[(1E)-2-phenyl-1-propenyl]-
There total 3 articles about Benzenamine, N,N-dimethyl-4-[(1E)-2-phenyl-1-propenyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper diacetate; palladium diacetate;
In
acetic acid; 1,2-dichloro-ethane;
at 60 ℃;
for 5h;
regioselective reaction;
Sealed tube;
DOI:10.1021/acs.joc.7b01570
- Guidance literature:
-
With
borane-ammonia complex; (3aR,7aR)-1,3-diisopropyl-2-((2-((E)-(quinolin-2-ylmethylene)amino)phenyl)amino)octahydro-1H-benzo[d][1,3,2]diazaphosphole 2-oxide; cobalt(II) bromide; sodium t-butanolate;
In
toluene;
at 60 ℃;
for 12h;
stereoselective reaction;
Glovebox;
Inert atmosphere;
DOI:10.1021/jacs.0c02101
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
1.2: 1 h / 50 °C / Inert atmosphere
2.1: (3aR,7aR)-1,3-diisopropyl-2-((2-((E)-(quinolin-2-ylmethylene)amino)phenyl)amino)octahydro-1H-benzo[d][1,3,2]diazaphosphole 2-oxide; cobalt(II) bromide; sodium t-butanolate; borane-ammonia complex / toluene / 12 h / 60 °C / Glovebox; Inert atmosphere
With
borane-ammonia complex; potassium tert-butylate; (3aR,7aR)-1,3-diisopropyl-2-((2-((E)-(quinolin-2-ylmethylene)amino)phenyl)amino)octahydro-1H-benzo[d][1,3,2]diazaphosphole 2-oxide; cobalt(II) bromide; sodium t-butanolate;
In
tetrahydrofuran; toluene;
1.1: |Wittig Olefination;
DOI:10.1021/jacs.0c02101