4-(Pyridin-3-yl)thiazol-2-amine

Base Information

• Chemical Name: 4-(Pyridin-3-yl)thiazol-2-amine
• CAS No.: 30235-27-9
• Molecular Formula: C8H7N3S
• Molecular Weight: 177.23
• Hs Code.: 2933399990
• European Community (EC) Number: 673-121-5
• DSSTox Substance ID: DTXSID80184332
• Nikkaji Number: J563.218H
• Wikidata: Q72441766
• ChEMBL ID: CHEMBL1188270
• Mol file: 30235-27-9.mol

Synonyms:30235-27-9;4-(pyridin-3-yl)thiazol-2-amine;2-Amino-4-(3-pyridyl)thiazole;4-Pyridin-3-yl-thiazol-2-ylamine;2-THIAZOLAMINE, 4-(3-PYRIDINYL)-;4-(3-Pyridinyl)-2-thiazolamine;4-pyridin-3-yl-1,3-thiazol-2-amine;4-(pyridin-3-yl)-1,3-thiazol-2-amine;CCRIS 6699;MFCD00218013;4-(3-pyridyl)-1,3-thiazol-2-amine;4-(3-pyridinyl)-1,3-thiazol-2-ylamine;SCHEMBL128811;4-(3-Pyridyl)-2-thiazolamine;CHEMBL1188270;4-(3-Pyridyl)-2-thiazoleamine;DTXSID80184332;3-(2-Aminothiazol-4-yl)pyridine;3-(2-amino-thiazol-4-yl)pyridine;4-pyridine-3-yl-thiazol-2-ylamine;AMY10492;4-(pyridin-3-yl)-thiazol-2-amine;2-amino-4-(pyridin-3-yl) thiazole;BBL020372;STK729355;AKOS000122310;AB04913;FS-1488;Thiazole, 2-amino-4-(pyridin-3-yl)-;4-(3-pyridyl)(1,3-thiazol-2-yl)amine;SY014181;2-amino-4-(pyridin-3-yl)-1,3-thiazole;LS-188560;CS-0072864;EN300-02252;A820270;J-513842;Z56914818;F0537-0970

Chemical Property of 4-(Pyridin-3-yl)thiazol-2-amine

Chemical Property:

• Vapor Pressure: 1.72E-06mmHg at 25°C
• Melting Point: 213 °C(Solv: ethanol (64-17-5))
• Refractive Index: 1.669
• Boiling Point: 396.3 °C at 760 mmHg
• PKA: 3.33±0.10(Predicted)
• Flash Point: 193.5 °C
• PSA: 80.04000
• Density: 1.333 g/cm³
• LogP: 2.36850
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 177.03606841
• Heavy Atom Count: 12
• Complexity: 153

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-4-(3-pyridyl)thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CN=C1)C2=CSC(=N2)N
• Uses: It is used as a pharmaceutical intermediate.

Technology Process of 4-(Pyridin-3-yl)thiazol-2-amine

There total 11 articles about 4-(Pyridin-3-yl)thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-(2-bromoacetyl)pyridine hydrobromide (17694-68-7) + thiourea (17356-08-0) → 4-(pyridin-3-yl)thiazol-2-amine (30235-27-9)

Guidance literature:

With potassium carbonate; In ethanol; for 5h; Reflux;

Reference yield: 94.0%

→ 4-(pyridin-3-yl)thiazol-2-amine (30235-27-9)

Guidance literature:

Reference yield: 92.0%

methyl-3-pyridylketone (350-03-8) + thiourea (17356-08-0) → 4-(pyridin-3-yl)thiazol-2-amine (30235-27-9)

Guidance literature:

methyl-3-pyridylketone; With hydrogen bromide; acetic acid; at 0 ℃; for 0.25h; Inert atmosphere;

With bromine; at 70 ℃; for 1h; Inert atmosphere;

thiourea; In ethanol; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2020.115683

upstream raw materials:

2-chloro-1-(pyridin-3-yl)ethan-1-one

thiourea

3-Bromoacetylpyridine

methyl-3-pyridylketone

Downstream raw materials:

4-(1,2,5,6-tetrahydro-1-propyl-3-pyridinyl)-2-thiazolamine

C₁₉H₁₈ClN₃OS

2-Hydrazino-4-(3'-pyridyl)thiazole

Refernces

• 1、 Wang, Linan,Qi, Junhui,Fan, Meixia,Yao, Lei. "Design, synthesis, and biological evaluation of urea-based ROCK2 inhibitors". . p. 969 - 978. Retrieved 2021/10/07.
• 2、 Kakati, Praachi,Singh, Preeti,Yadav, Priyanka,Awasthi, Satish Kumar. "Aiding the versatility of simple ammonium ionic liquids by the synthesis of bioactive 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives". . p. 6724 - 6738. Retrieved 2021/04/22.