2,7-Dihydroxy-9-fluorenone

Base Information

• Chemical Name: 2,7-Dihydroxy-9-fluorenone
• CAS No.: 42523-29-5
• Molecular Formula: C13H8O3
• Molecular Weight: 212.205
• Hs Code.: 2934999090
• European Community (EC) Number: 610-035-9
• DSSTox Substance ID: DTXSID60402283
• Nikkaji Number: J89.472I
• Wikidata: Q72466658
• ChEMBL ID: CHEMBL491290
• Mol file: 42523-29-5.mol

Synonyms:2,7-Dihydroxy-9-fluorenone;42523-29-5;2,7-dihydroxy-9H-fluoren-9-one;2,7-dihydroxyfluoren-9-one;2,7-Dihydroxyfluorenone;2,7-dihydroxy-fluoren-9-one;ChemDivAM_000848;ChemDiv1_019145;Oprea1_047542;Compound 0356-0002;SCHEMBL539276;CHEMBL491290;BDBM25808;HMS641G05;DTXSID60402283;CWHPQXRTQSNTRR-UHFFFAOYSA-N;AC-350;MFCD00037141;AKOS003625057;AM806675;AS-14445;A6934;CS-0096802;FT-0652019;EN300-113938;SR-01000390923;Q-101171;SR-01000390923-1;Z1464358023

Chemical Property of 2,7-Dihydroxy-9-fluorenone

Chemical Property:

• Appearance/Colour: Brown red powder
• Vapor Pressure: 1.63E-08mmHg at 25°C
• Melting Point: 338 °C
• Refractive Index: 1.749
• Boiling Point: 444.5 °C at 760 mmHg
• PKA: 8.87±0.20(Predicted)
• Flash Point: 236.7 °C
• PSA: 57.53000
• Density: 1.497 g/cm³
• LogP: 2.30920
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 212.047344113
• Heavy Atom Count: 16
• Complexity: 274

Purity/Quality:

99% ^*data from raw suppliers

2,7-Dihydroxy-9-fluorenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=C1O)C(=O)C3=C2C=CC(=C3)O
• Uses: 2,7-dihydroxy-9-fluorenone is used as organic intermediates.

Technology Process of 2,7-Dihydroxy-9-fluorenone

There total 24 articles about 2,7-Dihydroxy-9-fluorenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

9-oxo-9H-fluorene-2,7-diyl diacetate (53133-99-6) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Guidance literature:

With potassium hydroxide; for 2h; Heating;

DOI:10.1021/ma0350009

Reference yield: 95.0%

4,4'-dihydroxy-biphenyl-2-carboxylic acid methyl ester (765944-63-6) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Guidance literature:

With zinc(II) chloride; at 110 - 120 ℃; for 2h;

DOI:10.3390/molecules201219781

Reference yield: 90.0%

4,4'-dihydroxy-[1,1'-biphenyl]-2-carboxylic acid (53197-57-2) → 2,7-dihydroxy-9H-fluoren-9-one (42523-29-5)

Guidance literature:

With zinc(II) chloride; at 210 ℃; Neat (no solvent);

DOI:10.1039/c0pp00351d

upstream raw materials:

4,4'-dihydroxy-[1,1'-biphenyl]-2-carboxylic acid

2,7-dihydroxy-9-oxo-fluorene-1-carboxylic acid

2,7-dimethoxy-9H-fluorenon-9-one

9-oxo-9H-fluorene-2,7-diyl diacetate

Downstream raw materials:

9,9-bis(4-aminophenyl)-2,7-dihydroxyfluorenone

2,7-bis(2-diethylaminoethoxy)fluoren-9-one dihydrochloride

Refernces

• 1、 Lio, Jingdong,Haller, Marnie,Li, Hongxiang,Tang, Hong-Zhi,Jen, Alex K.-Y.,Jakka, Kavitha,Chou, Chia-Hung,Shu, Ching-Fong. "A Side-Chain Dendronized Nonlinear Optical Polyimide with Large and Thermally Stable Electrooptic Activity". . p. 248 - 250. Retrieved 2004.
• 2、 -. "MANUFACTURING METHOD OF HYDROXYFLUORENONES". Paragraph 0106-0108. . Retrieved 2019/06/21.
• 3、 Zhang, Junren,Yao, Qizheng,Liu, Zuliang,De Sousa, Maria Emília. "An effective synthesis method for tilorone dihydrochloride with obvious IFN-α inducing activity". . p. 21458 - 21463. Retrieved 2016/01/25.