5,6-Dichloro-2,3-dicyanopyrazine

Base Information

• Chemical Name: 5,6-Dichloro-2,3-dicyanopyrazine
• CAS No.: 56413-95-7
• Molecular Formula: C6Cl2N4
• Molecular Weight: 198.999
• Hs Code.: 2933990090
• Mol file: 56413-95-7.mol

Synonyms:5,6-dichloropyrazine-2,3-dicarbonitrile;

Chemical Property of 5,6-Dichloro-2,3-dicyanopyrazine

Chemical Property:

• Vapor Pressure: 0.000251mmHg at 25°C
• Melting Point: 183ºC
• Refractive Index: 1.612
• Boiling Point: 324.1 °C at 760 mmHg
• PKA: -12.94±0.10(Predicted)
• Flash Point: 149.8 °C
• PSA: 73.36000
• Density: 1.68 g/cm³
• LogP: 1.52676
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

5,6-Dichloro-2,3-dicyanopyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-Dichloro-2,3-dicyanopyrazine

There total 3 articles about 5,6-Dichloro-2,3-dicyanopyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,3-dioxo-1,2,3,4-tetrahydropyrazine-5,6-dicarbonitrile (36023-64-0) → 2,3-dichloro-5,6-dicyanopyrazine (56413-95-7)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In 1,4-dioxane; at 100 ℃; for 5h;

Reference yield: 45.0%

oxalyl dichloride (79-37-8) + 1,1-diamino-2,2-dicyanoethylene (1187-12-8) → 2,3-dichloro-5,6-dicyanopyrazine (56413-95-7)

Guidance literature:

oxalyl dichloride; 1,1-diamino-2,2-dicyanoethylene;

With thionyl chloride;

DOI:10.1002/ejoc.201101226

Reference yield:

→ 2,3-dichloro-5,6-dicyanopyrazine (56413-95-7)

Guidance literature:

upstream raw materials:

2,3-dioxo-1,2,3,4-tetrahydropyrazine-5,6-dicarbonitrile

oxalyl dichloride

1,1-diamino-2,2-dicyanoethylene

Downstream raw materials:

8-Benzyloxy-1,4,4b,9-tetraaza-fluorene-2,3-dicarbonitrile

5,8-Dibenzyl-5,6,7,8-tetrahydropyrazino<2,3-b>pyrazin-2,3-dicarbonitril

5-chloro-6-phenylsulfanyl-pyrazine-2,3-dicarbonitrile

2,3-dicyano-5-chloro-6-phenoxypyrazine

Refernces

• 1、 Keivanloo, Ali,Bakherad, Mohammad,Nasr-Isfahani, Hossein,Esmaily, Somayeh. "Highly efficient synthesis of 5,6-disubstituted-5H-pyrrolo[2,3-b]pyrazine- 2,3-dicarbonitriles through a one-pot palladium-catalyzed coupling reaction/cyclization in water". scheme or table. p. 3126 - 3130. Retrieved 2012/08/08.
• 2、 Morkved, Eva H.,Holmaas, Lars T.,Kjosen, Helge,Hvistendahl, Georg. "Preparation of magnesium azaphthalocyanines by cyclotetramerisation of S-substituted 4,5-disulfanylpyrazine-2,3-dicarbonitriles". . p. 1153 - 1156. Retrieved 2007/10/03.