2,3-Dimethoxybenzylamine

Base Information

• Chemical Name: 2,3-Dimethoxybenzylamine
• CAS No.: 4393-09-3
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.208
• Hs Code.: 29222900
• European Community (EC) Number: 224-515-7
• DSSTox Substance ID: DTXSID90195994
• Nikkaji Number: J205.773E
• Wikidata: Q72467730
• ChEMBL ID: CHEMBL555371
• Mol file: 4393-09-3.mol

Synonyms:2,3-Dimethoxybenzylamine;4393-09-3;(2,3-Dimethoxyphenyl)methanamine;1-(2,3-dimethoxyphenyl)methanamine;Benzenemethanamine, 2,3-dimethoxy-;o-Veratrylamine;2,3-Dimethoxy-benzylamine;[(2,3-Dimethoxyphenyl)methyl]amine;MFCD00052392;2,3-dimethoxy benzylamine;EINECS 224-515-7;2,3-dimethoxybenzyl amine;(2,3-dimethoxybenzyl)amine;2,3-dimethoxy benzyl amine;SCHEMBL622628;CHEMBL555371;2,3-Dimethoxybenzylamine, 99%;DTXSID90195994;(2,3-Dimethoxy-phenyl)methanamine;(2,3-Dimethoxyphenyl)methanamine #;BBL037741;STK503365;AKOS000151321;PS-4063;CS-0033736;D4022;FT-0635269;EN300-35059;O10578;J-500570;Z234895219

Chemical Property of 2,3-Dimethoxybenzylamine

Chemical Property:

• Appearance/Colour: Colorless to light yellow liquid
• Vapor Pressure: 0.00709mmHg at 25°C
• Melting Point: 229-230 °C(Solv: N,N-dimethylformamide (68-12-2))
• Refractive Index: n20/D 1.54(lit.)
• Boiling Point: 269.8 °C at 760 mmHg
• PKA: 9.12±0.10(Predicted)
• Flash Point: 113.5 °C
• PSA: 44.48000
• Density: 1.062 g/cm³
• LogP: 1.86280
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 167.094628657
• Heavy Atom Count: 12
• Complexity: 130

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dimethoxybenzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=CC(=C1OC)CN
• Uses: 2,3-Dimethoxybenzylamine was used in the synthesis of di-,tri- and tetrapeptide linked dicatechol derivatives and 1-aryl-2,3-dihydro-1H-isoindoles (isoindolines).

Technology Process of 2,3-Dimethoxybenzylamine

There total 6 articles about 2,3-Dimethoxybenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dimethyoxybenzaldehyde (86-51-1) → 2,3-dimethoxybenzyl amine (4393-09-3)

Guidance literature:

2,3-dimethyoxybenzaldehyde; In trimethyl orthoformate; at 25 ℃;

With lithium borohydride; In tetrahydrofuran; at 65 ℃; for 5h;

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 5h;

Reference yield:

C9H12NO2Pol → 2,3-dimethoxybenzyl amine (4393-09-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 5h; ((9-(amino)xanthen-2-yl)oxy)butanoic acid handle, p-methylbenzhydrylamine resin (H2N-XAL-MBHA resin)

Reference yield:

C9H10NO2Pol → 2,3-dimethoxybenzyl amine (4393-09-3)

Guidance literature:

C₉H₁₀NO₂Pol; With lithium borohydride; In tetrahydrofuran; at 65 ℃; for 5h;

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 5h;

upstream raw materials:

oxime of 2,3-dimethoxy-benzaldehyde

2,3-dimethoxybenzonitrile

2,3-dimethyoxybenzaldehyde

Downstream raw materials:

3-(aminomethyl)benzene-1,2-diol

N-(2,3-dimethoxy-benzyl)-β-alanine nitrile

N-t-butoxycarbonylglycine(2,3-dimethoxybenzyl)amide

Refernces

• 1、 -. "COMPOSITION OF SSAO SUBSTRATES AND METAL COMPOUNDS OF THE VLA AND VLB GROUPS OF THE PERIODIC TABLE". Page/Page column 25; 26. . Retrieved 2010/11/08.
• 2、 -. "Tetracyclic benzimidazole derivatives and combinatorial libraries thereof". . . Retrieved 2008/06/13.