4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine

Base Information

• Chemical Name: 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
• CAS No.: 857531-00-1
• Molecular Formula: C₂₀H₂₀ClN₃
• Molecular Weight: 337.852
• UNII: ERF7YL2CE2
• DSSTox Substance ID: DTXSID00457772
• Wikidata: Q27097070
• Metabolomics Workbench ID: 151014
• ChEMBL ID: CHEMBL428462
• Mol file: 857531-00-1.mol

Synonyms:AT 7867;AT-7867;AT7867

Chemical Property of 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine

Chemical Property:

• Boiling Point: 530.2 °C at 760 mmHg
• Flash Point: 274.5 °C
• PSA: 40.71000
• Density: 1.214 g/cm³
• LogP: 4.72840
• Solubility.: ≥16.9 mg/mL in DMSO; ≥4.38 mg/mL in EtOH with ultrasonic; ≥45 mg/mL in H2O
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 337.1345753
• Heavy Atom Count: 24
• Complexity: 394

Purity/Quality:

98%,99%, ^*data from raw suppliers

AT7867 ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl
• Recent ClinicalTrials: Gemcitabine,Vincristine and Cisplatin as Second Line Combination Therapy in Patients With Sarcoma
• Description: AT7867 is a potent and orally bioavailable inhibitor of Akt isoforms Akt1, 2, and 3 (IC50s = 32, 17, and 47 nM, respectively). It also inhibits p70S6 kinase and PKA (IC50s = 85 and 20 nM, respectively), but is without effect against a panel of other kinases. AT7867 inhibits growth and induces apoptosis in a variety of cancer cell lines in vitro and suppresses tumor growth of PTEN-deficient xenografts in mice.
• Uses: A potent Akt inhibitor with an IC50 of 17 nM. AT7867 also inhibits structurally related AGC kinases p70S6K and PKA with IC50s of 20 nM and 85 nM, respectively.

Technology Process of 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine

There total 1 articles about 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ AT7867 (857531-00-1)

Guidance literature:

Refernces

• 1、 -. "PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS". Page/Page column 118-119. . Retrieved 2010/02/12.