Hydrazinecarboxamide, 2-(2-hydrazino-6,7-dimethoxy-4-quinazolinyl)-, monohydrochloride

Base Information

• Chemical Name: Hydrazinecarboxamide, 2-(2-hydrazino-6,7-dimethoxy-4-quinazolinyl)-, monohydrochloride
• CAS No.: 134749-27-2
• Molecular Formula: C11H15 N7 O3 . Cl H
• Molecular Weight: 329.746
• DSSTox Substance ID: DTXSID10158925
• Mol file: 134749-27-2.mol

Synonyms:6,7-Dimethoxy-4-semicarbazido-2-hydrazinoquinazoline hydrochloride;Hydrazinecarboxamide, 2-(2-hydrazino-6,7-dimethoxy-4-quinazolinyl)-, monohydrochloride;2-(2-Hydrazino-6,7-dimethoxy-4-quinazolinyl)hydrazinecarboxamide monohydrochloride;134749-27-2;C11H15N7O3.ClH;DTXSID10158925;C11-H15-N7-O3.Cl-H;LS-76604

Chemical Property of Hydrazinecarboxamide, 2-(2-hydrazino-6,7-dimethoxy-4-quinazolinyl)-, monohydrochloride

Chemical Property:

• Vapor Pressure: 6.52E-14mmHg at 25°C
• Boiling Point: 583.6°Cat760mmHg
• Flash Point: 306.7°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 329.1003151
• Heavy Atom Count: 22
• Complexity: 359

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)NN)NNC(=O)N)OC.Cl

Technology Process of Hydrazinecarboxamide, 2-(2-hydrazino-6,7-dimethoxy-4-quinazolinyl)-, monohydrochloride

There total 2 articles about Hydrazinecarboxamide, 2-(2-hydrazino-6,7-dimethoxy-4-quinazolinyl)-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-chloro-6,7-dimethoxy-4-semicarbazidoquinazoline (134749-19-2) → 6,7-dimethoxy-4-semicarbazido-2-hydrazinoquinazoline hydrochloride (134749-27-2)

Guidance literature:

With hydrazine hydrate; In ethanol; acetonitrile; for 6h; Heating;

DOI:10.1007/BF00766359

Reference yield:

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one (27631-29-4) → 6,7-dimethoxy-4-semicarbazido-2-hydrazinoquinazoline hydrochloride (134749-27-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / dimethylformamide / 24 h / Ambient temperature

2: 74 percent / hydrazine hydrate / acetonitrile; ethanol / 6 h / Heating

With hydrazine hydrate; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1007/BF00766359

upstream raw materials:

2-chloro-6,7-dimethoxy-4-semicarbazidoquinazoline

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

Refernces