1-(PHENYLSULFONYL)-1H-PYRROLE-2-CARBALDEHYDE

Base Information

• Chemical Name: 1-(PHENYLSULFONYL)-1H-PYRROLE-2-CARBALDEHYDE
• CAS No.: 86688-93-9
• Molecular Formula: C11H9NO3S
• Molecular Weight: 235.263
• Hs Code.: 2933990090
• Mol file: 86688-93-9.mol

Synonyms:1-(phenylsulfonyl)pyrrole-2-carbaldehyde;1-(Phenylsulfonyl)-2-pyrrolecarboxaldehyde;1-(Phenylsulfonyl)-1H-pyrrole-2-carbaldehyde;1-phenylsulfonylpyrrole-2-carboxaldehyde;1-(phenylsulfonyl)-1H-pyrrole-2-carboxaldehyde;1-(phenylsulfonyl)-2-pyrrolecarboxyaldehyde;

Chemical Property of 1-(PHENYLSULFONYL)-1H-PYRROLE-2-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 7.01E-08mmHg at 25°C
• Melting Point: 81-82oC(lit.)
• Boiling Point: 438.2oC at 760 mmHg
• Flash Point: 218.8oC
• PSA: 64.52000
• Density: 1.29g/cm3
• LogP: 2.61840

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(Phenylsulfonyl)-2-pyrrolecarboxaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 1-(PHENYLSULFONYL)-1H-PYRROLE-2-CARBALDEHYDE

There total 7 articles about 1-(PHENYLSULFONYL)-1H-PYRROLE-2-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-phenylsulfonylpyrrole (16851-82-4) + Dichloromethyl methyl ether (4885-02-3) → 1-benzenesulfonyl-2-formylpyrrole (86688-93-9)

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane; at 0 ℃; for 3h;

DOI:10.1021/jo00167a014

Reference yield: 97.0%

2-pyrrole aldehyde (1003-29-8,254729-95-8) + benzenesulfonyl chloride (98-09-9) → 1-benzenesulfonyl-2-formylpyrrole (86688-93-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1.25h;

DOI:10.1016/S0968-0896(00)00274-1

Reference yield: 90.0%

(1-benzenesulfonylpyrrol-2-yl)-(3-benzyloxymethyl-2-methylsulfanyl-5-vinylimidazol-4-yl)methanol (883458-90-0) → 1-benzenesulfonyl-2-formylpyrrole (86688-93-9)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃;

DOI:10.1021/jo0707232

upstream raw materials:

2-pyrrole aldehyde

benzenesulfonyl chloride

N-phenylsulfonylpyrrole

dichloromethyl n-butyl ether

Downstream raw materials:

2-methyl-3-{[1-(phenylsulfonyl)-1H-pyrrol-2-yl]methyl}-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

2-ethenyl-1-phenylsulfonyl-1H-pyrrole

C₁₃H₁₃NO₄S

1-(1-(phenylsulfonyl)-1H-pyrrol-2-yl)non-8-en-1-ol

Refernces

• 1、 Fu, Zhangyu,Hou, Yingwei,Ji, Cunpeng,Ma, Mingxu,Tian, Zhenhua,Deng, Mengyan,Zhong, Lili,Chu, Yanyan,Li, Wenbao. "Design, synthesis and biological evaluation of anti-pancreatic cancer activity of plinabulin derivatives based on the co-crystal structure". . p. 2061 - 2072. Retrieved 2018/03/26.
• 2、 Meketa, Matthew L.,Weinreb, Steven M.,Nakao, Yoichi,Fusetani, Nobuhiro. "Application of a 6π-1-azatriene electrocyclization strategy to the total synthesis of the marine sponge metabolite ageladine A and biological evaluation of synthetic analogues". . p. 4892 - 4899. Retrieved 2008/02/05.