Propionyl fluoride

Base Information

• Chemical Name: Propionyl fluoride
• CAS No.: 430-71-7
• Molecular Formula: C3H5FO
• Molecular Weight: 76.0705
• Hs Code.: 2915900090
• European Community (EC) Number: 207-067-7
• UNII: B3MR4M73ZQ
• DSSTox Substance ID: DTXSID7059987
• Nikkaji Number: J134.405F
• Wikidata: Q81989027
• Mol file: 430-71-7.mol

Synonyms:Propionyl fluoride;Propanoyl fluoride;430-71-7;B3MR4M73ZQ;EINECS 207-067-7;propionylfluoride;Propanoyl-fluoride-;UNII-B3MR4M73ZQ;DTXSID7059987;MFCD00039220;AKOS006227575;FT-0676086;A826138

Chemical Property of Propionyl fluoride

Chemical Property:

• Vapor Pressure: 369mmHg at 25°C
• Refractive Index: 1.323
• Boiling Point: 44 °C at 760 mmHg
• Flash Point: 3.2 °C
• PSA: 17.07000
• Density: 0.943 g/cm³
• LogP: 0.89250
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 76.032442941
• Heavy Atom Count: 5
• Complexity: 42.2

Purity/Quality:

98%min ^*data from raw suppliers

Propionyl fluoride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C, F
• Hazard Codes: C,F
• Statements: 11-34
• Safety Statements: 16-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)F

Technology Process of Propionyl fluoride

There total 11 articles about Propionyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

propionyl chloride (79-03-8) → propionyl fluoride (430-71-7)

Guidance literature:

With pyridine hydrogenfluoride; In 1,4-dioxane; at 20 ℃; for 0.0833333h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201202292

Reference yield: 60.0%

propionic acid (802294-64-0,79-09-4) → propionyl fluoride (430-71-7)

Guidance literature:

With perfluoro-2-methyl-2-pentene; triethylamine; In toluene; for 3h; Ambient temperature;

DOI:10.1246/bcsj.54.1151

Reference yield:

propionyl chloride (79-03-8) + propionic acid anhydride (123-62-6) → propionyl fluoride (430-71-7)

Guidance literature:

With potassium fluoride hydrofluoride; at 120 ℃;

upstream raw materials:

N-(2-chloro-1,1,2-trifluoroethyl)diethylamine

sodium proprionate

propionyl chloride

propionic acid anhydride

Downstream raw materials:

4-nitrophenyl propionate

N-methyl-N-phenylpropanamide

N,N-diethylpropanamide

N-(4-methoxyphenyl)-propanamide

Refernces

• 1、 Hayatifar, Ardalan,Elifritz, Emily A.,Bloom, Molly B.,Pixley, Kaitlyn M.,Fennell, Christopher J.,Weinert, Charles S.. "Direct amidation of acid fluorides using germanium amides". supporting information. p. 4490 - 4493. Retrieved 2021/04/12.
• 2、 -. "METHOD FOR PRODUCING FLUORINATED HYDROCARBONS". Paragraph 0102-0103. . Retrieved 2020/01/12.