2,6-Dichloro-3,5-dimethoxyaniline

Base Information

• Chemical Name: 2,6-Dichloro-3,5-dimethoxyaniline
• CAS No.: 872509-56-3
• Molecular Formula: C8H9Cl2NO2
• Molecular Weight: 222.071
• Hs Code.: 2922299090
• Mol file: 872509-56-3.mol

Synonyms:2,6-Dichloro-3,5-dimethoxyaniline;

Chemical Property of 2,6-Dichloro-3,5-dimethoxyaniline

Chemical Property:

• Boiling Point: 320℃
• PKA: -0.13±0.10(Predicted)
• Flash Point: 147℃
• PSA: 44.48000
• Density: 1.357
• LogP: 3.17400
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,6-Dichloro-3,5-dimethoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Dichloro-3,5-dimethoxyaniline

There total 6 articles about 2,6-Dichloro-3,5-dimethoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,6-dichloro-3,5-dimethoxybenzamide → 2,6-dichloro-3,5-dimethoxy-phenylamine (872509-56-3)

Guidance literature:

With bromine; sodium methylate; In methanol; at 0 ℃; for 6h; Reagent/catalyst; Solvent; Temperature; Reflux;

Reference yield: 92.0%

N-(2,6-dichloro-3,5-dimethoxy-phenyl)-acetamide (943189-21-7) → 2,6-dichloro-3,5-dimethoxy-phenylamine (872509-56-3)

Guidance literature:

With potassium hydroxide; In ethanol; for 44h; Reflux;

DOI:10.1021/jm2006222

Reference yield:

N-(3,5-dimethoxy-phenyl)-acetamide (79257-61-7) → 2,6-dichloro-3,5-dimethoxy-phenylamine (872509-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuryl dichloride / acetonitrile / 0.5 h / 0 °C / Inert atmosphere

2: potassium hydroxide / ethanol / 44 h / Reflux

With sulfuryl dichloride; potassium hydroxide; In ethanol; acetonitrile;

DOI:10.1021/jm2006222

upstream raw materials:

N-(2,6-dichloro-3,5-dimethoxy-phenyl)-acetamide

N-(3,5-dimethoxy-phenyl)-acetamide

3.5-dimethoxyaniline

3,5-dimethoxybenzoic acid

Downstream raw materials:

2,4-dichloro-3-isocyanato-1,5-methoxy-4-methylbenzene

1-(6-chloropyrimidin-4-yl)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylurea

Refernces

• 1、 -. "Pyrido[2,3-b]pyrazine-3(4H)-ketone derivative and application thereof". Paragraph 0019-0020; 0038; 0040. . Retrieved 2021/03/13.
• 2、 -. "HETEROARYLAMINE DERIVATIVES AS PROTEIN KINASE INHIBITORS". Paragraph 0098; 0099. . Retrieved 2016/06/21.