4-ISOPROPYLPHENOXYACETIC ACID

Base Information

• Chemical Name: 4-ISOPROPYLPHENOXYACETIC ACID
• CAS No.: 1643-16-9
• Molecular Formula: C11H14 O3
• Molecular Weight: 194.23
• Hs Code.: 2918990090
• Mol file: 1643-16-9.mol

Synonyms:Aceticacid, (p-cumenyloxy)- (6CI,7CI,8CI); Acetic acid, [4-(1-methylethyl)phenoxy]-(9CI); 4-Isopropylphenoxyacetic acid; [(4-Isopropylphenyl)oxy]acetic acid;[[4-(1-Methylethyl)phenyl]oxy]acetic acid

Chemical Property of 4-ISOPROPYLPHENOXYACETIC ACID

Chemical Property:

• Vapor Pressure: 0.000188mmHg at 25°C
• Melting Point: 85-87°C
• Refractive Index: 1.4980 (589.3 nm 20℃)
• Boiling Point: 315.2°Cat760mmHg
• PKA: 3.21±0.10(Predicted)
• Flash Point: 120°C
• PSA: 46.53000
• Density: 1.112g/cm³
• LogP: 2.27340
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Isopropylphenoxy)aceticAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ISOPROPYLPHENOXYACETIC ACID

There total 9 articles about 4-ISOPROPYLPHENOXYACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl (4-(1-methylethyl)phenoxy)acetate (184878-97-5) → 2-(4-isopropylphenoxy)acetic acid (1643-16-9)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 1.5h;

DOI:10.3390/antibiotics10040438

Reference yield: 94.0%

(4-isopropylphenyl)acetic acid ethyl ester (14062-21-6) → 2-(4-isopropylphenoxy)acetic acid (1643-16-9)

Guidance literature:

(4-isopropylphenyl)acetic acid ethyl ester; With sodium hydroxide; water; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In methanol; water;

Reference yield: 93.0%

tert-butyl 2-(4-isopropylphenoxy)acetate (1401223-60-6) → 2-(4-isopropylphenoxy)acetic acid (1643-16-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jm400221d

upstream raw materials:

4-Isopropylphenol

chloroacetic acid

ethyl (4-isopropylphenoxy)acetate

(4-isopropylphenyl)acetic acid ethyl ester

Downstream raw materials:

4,5-dihydro-4,4-dimethyl-2-(4-isopropylphenoxymethyl)oxazole

C₁₉H₂₅N₃O₃

C₃₂H₃₀N₂O₆

N-isopropyl-2-(4-isopropylphenoxy)-N-((3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)methyl)acetamide

Refernces

• 1、 Suigo, Lorenzo,Chojnacki, Michaelle,Zanotto, Carlo,Sebastián-Pérez, Victor,Morghen, Carlo De Giuli,Casiraghi, Andrea,Dunman, Paul M.,Valoti, Ermanno,Straniero, Valentina. "Staphylococcus aureus rnpa inhibitors: Computational-guided design, synthesis and initial biological evaluation". . . Retrieved 2021/05/04.
• 2、 Takahashi, Eiki,Hirano, Noriyuki,Nagahara, Takashi,Yoshikawa, Satoru,Momen, Shinobu,Yokokawa, Hiroshi,Hayashi, Ryoji. "Discovery of potent transient receptor potential vanilloid 1 antagonists: Design and synthesis of phenoxyacetamide derivatives". . p. 3154 - 3156. Retrieved 2013/06/26.