n-(1-Naphthyl)benzenesulfonamide

Base Information

• Chemical Name: n-(1-Naphthyl)benzenesulfonamide
• CAS No.: 15309-82-7
• Molecular Formula: C16H13 N O2 S
• Molecular Weight: 283.351
• NSC Number: 77046
• DSSTox Substance ID: DTXSID70291665
• Nikkaji Number: J1.604.829A
• Wikidata: Q82029681
• ChEMBL ID: CHEMBL1536820
• Mol file: 15309-82-7.mol

Synonyms:n-(1-naphthyl)benzenesulfonamide;15309-82-7;N-(naphthalen-1-yl)benzenesulfonamide;N-naphthalen-1-ylbenzenesulfonamide;NSC77046;Maybridge3_002754;phenylsulfonylaminonaphthalene;MLS000777198;SCHEMBL1428546;CHEMBL1536820;DTXSID70291665;HMS1438N04;HMS2757P13;MFCD00422468;N-Naphthalen-1-yl-benzenesulfonamide;NSC-77046;STK069319;AKOS000493557;n-(naphthalen-1-yl)benzenesulphonamide;IDI1_014141;NCGC00161721-01;SMR000413594;CS-0324301;AE-641/01970014;CU-00000000147-1

Chemical Property of n-(1-Naphthyl)benzenesulfonamide

Chemical Property:

• Vapor Pressure: 3.59E-09mmHg at 25°C
• Melting Point: 165-167 °C
• Boiling Point: 474.5°Cat760mmHg
• PKA: 8.51±0.30(Predicted)
• Flash Point: 240.8°C
• PSA: 54.55000
• Density: 1.332g/cm³
• LogP: 4.79440
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 283.06669983
• Heavy Atom Count: 20
• Complexity: 409

Purity/Quality:

99% ^*data from raw suppliers

N-(Naphthalen-1-yl)benzenesulfonamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC3=CC=CC=C32

Technology Process of n-(1-Naphthyl)benzenesulfonamide

There total 11 articles about n-(1-Naphthyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-amino-naphthalene (134-32-7) + benzenesulfonyl chloride (98-09-9) → N-(naphthalen-1-yl)benzenesulfonamide (15309-82-7)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.0c02094

Reference yield: 65.0%

1-Nitronaphthalene (86-57-7) + phenylboronic acid (98-80-6) → N-(naphthalen-1-yl)benzenesulfonamide (15309-82-7)

Guidance literature:

With potassium pyrosulfite; tetrabutyl-ammonium chloride; potassium carbonate; In acetonitrile; at 130 ℃; for 24h; Sealed tube;

Reference yield: 57.0%

phenylsulfonyl azide (938-10-3) + 1-Bromonaphthalene (90-11-9) → N-(naphthalen-1-yl)benzenesulfonamide (15309-82-7)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; copper; potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 24h;

DOI:10.1007/s13738-012-0115-2

upstream raw materials:

naphthalene

benzylsulfonyl azide

sodium acetate

1-amino-naphthalene

Downstream raw materials:

C₂₃H₂₃NO₄S

N-(4-bromo-2-nitro-[1]naphthyl)-benzenesulfonamide

1-benzenesulfonamido-2,4-diaminonaphthalene

N-(1-amino-4-bromo-[2]naphthyl)-benzenesulfonamide

Refernces

• 1、 Pallesen, Jakob S.,Narayanan, Dilip,Tran, Kim T.,Solbak, Sara M. ?.,Marseglia, Giuseppe,S?rensen, Louis M. E.,H?j, Lars J.,Munafò, Federico,Carmona, Rosa M. C.,Garcia, Anthony D.,Desu, Haritha L.,Brambilla, Roberta,Johansen, Tommy N.,Popowicz, Grzegorz M.,Sattler, Michael,Gajhede, Michael,Bach, Anders. "Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds". . p. 4623 - 4661. Retrieved 2021/05/07.
• 2、 -. "Sulfonamide compound and metal-free catalytic construction method and application thereof". Paragraph 0121-0125. . Retrieved 2020/07/21.