Antibiotic SL 7810F

Base Information

• Chemical Name: Antibiotic SL 7810F
• CAS No.: 54651-05-7
• Molecular Formula: C₅₂H₈₁N₇O₁₆
• Molecular Weight: 1060.25
• Wikidata: Q105104753
• Wikipedia: Echinocandin_B
• Mol file: 54651-05-7.mol

Synonyms:echinocandin B

Chemical Property of Antibiotic SL 7810F

Chemical Property:

• PSA: 368.19000
• LogP: 0.25150
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 14
• Hydrogen Bond Acceptor Count: 16
• Rotatable Bond Count: 20
• Exact Mass: 1059.57397952
• Heavy Atom Count: 75
• Complexity: 1940

Purity/Quality:

99% ^*data from raw suppliers

EchinocandinB,60% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCC=CCC=CCCCCCCCC(=O)NC1CC(C(NC(=O)C2C(C(CN2C(=O)C(NC(=O)C(NC(=O)C3CC(CN3C(=O)C(NC1=O)C(C)O)O)C(C(C4=CC=C(C=C4)O)O)O)C(C)O)C)O)O)O
• Isomeric SMILES: CCCCC/C=C\C/C=C\CCCCCCCC(=O)N[C@H]1C[C@H]([C@H](NC(=O)[C@@H]2[C@H]([C@H](CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC1=O)[C@H](C)O)O)[C@@H]([C@H](C4=CC=C(C=C4)O)O)O)[C@H](C)O)C)O)O)O
• Uses: Echinocandin B is the major analogue of a family of lipopeptides isolated from several species of Aspergillus, reported in 1974. Echinocandin B is a potent antifungal and acts by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi. Echinocandin B is a potent antifungal that acts by inhibition of the synthesis of ?(1,3)-D-glucan.

Technology Process of Antibiotic SL 7810F

There total 1 articles about Antibiotic SL 7810F which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ cyclo-[(4R,5R)-4,5-dihydroxy-N2-octadeca-9c,12c-dienoyl-L-ornithyl->-L-threonyl->-4c-hydroxy-(2rH)-L-prolyl->-(4S)-4-hydroxy-4-(4-hydroxy-phenyl)-L-threonyl->-L-threonyl->-3c-hydroxy-4c-methyl-(2rH)-L-prolyl-(1->N5)] (54651-05-7,79814-65-6)

Guidance literature:

Isolierung aus aspergillus rugulosus;

DOI:10.1002/hlca.19790620436

Reference yield: 42.0%

echinocandin B (54651-05-7) → C52H81N7O14 (144540-61-4)

Guidance literature:

With sodium cyanoborohydride; In tetrahydrofuran; for 0.0333333h;

DOI:10.1016/S0040-4039(00)61304-7

Reference yield: 10.0%

echinocandin B (54651-05-7) → C52H81N7O14 (144540-61-4) + echinocandin C (71018-12-7)

Guidance literature:

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; for 0.0166667h; Ambient temperature;

DOI:10.1016/S0040-4039(00)61304-7

Downstream raw materials:

C₅₂H₈₁N₇O₁₄

echinocandin C