2-(4-Methoxyphenoxy)benzaldehyde

Base Information

• Chemical Name: 2-(4-Methoxyphenoxy)benzaldehyde
• CAS No.: 19434-36-7
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• Hs Code.: 2912499000
• European Community (EC) Number: 623-913-1
• DSSTox Substance ID: DTXSID80377621
• Nikkaji Number: J2.763.326I
• Wikidata: Q82166901
• ChEMBL ID: CHEMBL1319962
• Mol file: 19434-36-7.mol

Synonyms:2-(4-Methoxyphenoxy)benzaldehyde;19434-36-7;2-(4-methoxyphenoxy)benzenecarbaldehyde;SMR000179268;MLS000326724;Benzaldehyde,2-(4-methoxyphenoxy)-;SCHEMBL1200307;CHEMBL1319962;BDBM56496;cid_2767673;AML0020;DTXSID80377621;HMS2159P06;HMS3311D04;MFCD01568732;AKOS000260655;2-(4-Methoxyphenoxy)benzaldehyde, 97%;CS-0328412;FT-0637849;10.14272/ZPGJUBFCROCTOT-UHFFFAOYSA-N;E82683;11N-047;A813724;doi:10.14272/ZPGJUBFCROCTOT-UHFFFAOYSA-N;J-506034

Chemical Property of 2-(4-Methoxyphenoxy)benzaldehyde

Chemical Property:

• Vapor Pressure: 7.68E-05mmHg at 25°C
• Melting Point: 57-61 °C
• Refractive Index: 1.59
• Boiling Point: 342.1 °C at 760 mmHg
• Flash Point: 151.9 °C
• PSA: 35.53000
• Density: 1.166 g/cm³
• LogP: 3.30000
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 228.078644241
• Heavy Atom Count: 17
• Complexity: 234

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Methoxyphenoxy)benzenecarbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,N
• Hazard Codes: Xi,N
• Statements: 41-43-50
• Safety Statements: 26-36/37/39-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)OC2=CC=CC=C2C=O

Technology Process of 2-(4-Methoxyphenoxy)benzaldehyde

There total 9 articles about 2-(4-Methoxyphenoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Fluorobenzaldehyde (446-52-6) + 4-methoxy-phenol (150-76-5) → 2-(4-methoxyphenoxy)benzaldehyde (19434-36-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; at 170 ℃; for 4h;

DOI:10.1021/ol4000857

Reference yield: 86.0%

4-methoxy-phenol (150-76-5) + ortho-bromobenzaldehyde (6630-33-7) → 2-(4-methoxyphenoxy)benzaldehyde (19434-36-7)

Guidance literature:

With potassium carbonate; In water; for 2.16667h; Reflux; Green chemistry;

DOI:10.1002/aoc.4463

Reference yield: 85.0%

4-methoxy-phenol (150-76-5) + 2-nitro-benzaldehyde (552-89-6) → 2-(4-methoxyphenoxy)benzaldehyde (19434-36-7)

Guidance literature:

With copper(II) acetate monohydrate; caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tet.2012.08.032

upstream raw materials:

2-Fluorobenzaldehyde

4-methoxy-phenol

1-bromo-4-methoxy-benzene

4-methoxyphenylboronic acid

Downstream raw materials:

(2-hydroxyphenyl)(4-methoxyphenyl)methanone

C₁₈H₁₉N₃O₃

C₁₇H₁₆O₄

N-{(E)-3-[2-(4-hydroxy-phenoxy)-phenyl]-2-methyl-acryloyl}-guanidine

Refernces

• 1、 Shi, Zeyu,Chen, Si,Xiao, Qiong,Yin, Dali. "Formation and Disproportionation of Xanthenols to Xanthenes and Xanthones and Their Use in Synthesis". . p. 3334 - 3343. Retrieved 2021/02/05.
• 2、 Prajapati, Anamika,Kumar, Mahendra,Thakuria, Ranjit,Basak, Ashok K.. "In(OTf)3 catalyzed reductive etherification of 2-aryloxybenzaldehydes and 2-(arylthio)benzaldehydes". supporting information. . Retrieved 2019/10/02.