[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine

Base Information

• Chemical Name: [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine
• CAS No.: 5915-16-2
• Molecular Formula: C5H5N5
• Molecular Weight: 135.128
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60376975
• Nikkaji Number: J3.013.877E
• Wikidata: Q82165958
• Mol file: 5915-16-2.mol

Synonyms:[1,2,4]triazolo[1,5-a]pyrimidin-7-amine;5915-16-2;SCHEMBL1650004;DTXSID60376975;1,5,7,9-tetrazabicyclo[4.3.0]nona-2,4,6,8-tetraen-2-amine;MFCD00232059;7-amino-s-triazolo[1,5-a]pyrimidine;AKOS002682655;AT12475;[1,2,4]Triazolo[1,5a]pyrimidin-7-amine;7-Amino[1,2,4]triazolo[1,5-a]pyrimidine;CS-0081101;FT-0648644;1D-106;D74285;EN300-123664;A869259;J-502705;Z1201619881;1 pound not5 pound not7 pound not9-tetrazabicyclo[4.3.0]nona-2 pound not4 pound not6 pound not8-tetraen-2-amine

Chemical Property of [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine

Chemical Property:

• Melting Point: 278-280°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 69.10000
• Density: 1.74g/cm³
• LogP: 0.28770
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 135.05449518
• Heavy Atom Count: 10
• Complexity: 127

Purity/Quality:

99%, ^*data from raw suppliers

[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N2C(=NC=N2)N=C1)N

Technology Process of [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine

There total 6 articles about [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-dimethylaminoacrylonitrile (2407-68-3) + 3-amino-1,2,4-triazole (61-82-5) → 7-amino-1,2,4-triazolo[1,5-a]pyrimidine (5915-16-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 2h; Reflux;

DOI:10.1002/jhet.3222

Reference yield: 75.0%

(E)-β-morpholino acrylonitrile (23220-67-9) + 3-amino-1,2,4-triazole (61-82-5) → 7-amino-1,2,4-triazolo[1,5-a]pyrimidine (5915-16-2)

Guidance literature:

With pyridine; acetic acid; at 150 ℃; for 5h;

DOI:10.1007/s10593-019-02498-2

Reference yield: 72.0%

3,3-bis(ethyloxy)propanenitrile (2032-34-0) + 3-amino-1,2,4-triazole (61-82-5) → 7-amino-1,2,4-triazolo[1,5-a]pyrimidine (5915-16-2) + [1,2,4]triazolo[4,3-a]pyrimidin-5-amine

Guidance literature:

With hydrogenchloride; In ethanol; water; Reflux;

DOI:10.1007/s10593-019-02498-2

upstream raw materials:

β-piperidinoacrylonitrile

3-amino-1,2,4-triazole

3-dimethylaminoacrylonitrile

(E)-β-morpholino acrylonitrile

Downstream raw materials:

2,4,6-Trichlorophenol

Refernces

• 1、 Alnajjar, Abdulaziz,Abdelkhalik, Mervat Mohammed,Raslan, Mohamed Abdelmonem,Ibraheem, Solwan Maher,Sadek, Kamal Usef. "Synthesis of New [1,2,4]Triazolo[1,5-a]pyrimidine Derivatives: Reactivity of 3-Amino[1,2,4]triazole towards Enaminonitriles and Enaminones". . p. 1804 - 1808. Retrieved 2018/07/25.
• 2、 -. "FAT ACCUMULATION INHIBITORY AGENTS". . . Retrieved 2008/06/13.