N,N-Dimethylacetamide dimethyl acetal

Base Information

• Chemical Name: N,N-Dimethylacetamide dimethyl acetal
• CAS No.: 18871-66-4
• Molecular Formula: C6H15NO2
• Molecular Weight: 133.191
• Hs Code.: 29241990
• European Community (EC) Number: 242-641-0
• DSSTox Substance ID: DTXSID10172242
• Nikkaji Number: J208.388D
• Wikidata: Q72467893
• Mol file: 18871-66-4.mol

Synonyms:18871-66-4;N,N-Dimethylacetamide dimethyl acetal;1,1-dimethoxy-n,n-dimethylethanamine;1,1-Dimethoxy-N,N-dimethylethylamine;(1,1-dimethoxyethyl)dimethylamine;1,1-Dimethoxyethyl(dimethyl)amine;Ethanamine, 1,1-dimethoxy-N,N-dimethyl-;dimethylacetamide dimethyl acetal;EINECS 242-641-0;(1,1-Dimethoxy-ethyl)-dimethyl-amine;Dimethylacetamide Dimethylacetal;SCHEMBL1890;dimethylacetamide-dimethyacetal;dimethylacetamide-dimethylacetal;1,1-Dimethoxyethyldimethylamine;dimethoxy-N,N-dimethylethanamine;dimethyl acetamide dimethyl acetal;DTXSID10172242;N,N-Dimethylacetamide dimethylacetal;n,n-dimethylacetamide-dimethylacetal;N,N-dimethylacetamide dimethyl ketal;(1,1-dimethoxy-ethyl)-dimethylamine;MFCD00008476;n,n-dimethyl-acetamide dimethylacetal;N-(1,1-Dimethoxyethyl)dimethylamine;AKOS000121156;N, N dimethylacetamide-dimethyl acetal;N,N-Dimethyl acetamide dimethyl acetal;N,N-Dimethylacet-amide dimethyl acetal;N,N-Dimethylacetamide dimethyl acetal, stabilized with 5-10% Methanol;1,1-dimethoxy-N,N-dimethyl-ethanamine;1,I-dimethoxy-N,N-dimethyl-ethanamine;CS-W001231;1,1 -dimethoxy-N,N-dimethyl-ethanamine;AS-18685;N,N-dimethyl-1,1-bis(methyloxy)ethanamine;N-(1,1-dimethoxyethyl)-N,N-dimethylamine;N,N-Dimethylacetamide dimethyl acetal, 90%;BB 0256479;D1652;FT-0629515;FT-0629516;EN300-26228;D77636;W-107751;ETHYL5-CHLORO-3-PHENYL-1H-INDOLE-2-CARBOXYLATE;F0001-0678;N,N-Dimethylacetamide dimethyl acetal (stab. with CH3OH)

Chemical Property of N,N-Dimethylacetamide dimethyl acetal

Chemical Property:

• Appearance/Colour: coloress to pale yellow liquid
• Vapor Pressure: 19.3mmHg at 25°C
• Refractive Index: n20/D 1.411(lit.)
• Boiling Point: 115.133 °C at 760 mmHg
• PKA: 5.08±0.50(Predicted)
• Flash Point: 8.333 °C
• PSA: 21.70000
• Density: 0.902 g/cm³
• LogP: 0.51450
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• Water Solubility.: Hydrolyzes in water.
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 133.110278721
• Heavy Atom Count: 9
• Complexity: 79.1

Purity/Quality:

99% ^*data from raw suppliers

N,N-Dimethylacetamide Dimethyl Acetal ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xn
• Hazard Codes: F,Xn
• Statements: 11-20/21/22-36/37/38-68/20/21/22-68
• Safety Statements: 26-36/37-36/37/39-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(N(C)C)(OC)OC
• Uses: N,N-Dimethylacetamide dimethyl acetal has been used as:one carbon inserting synthon in preparation of pyrimido[1,2-a][1,3,5]triazin-6-onesreagent for the synthesis of amides, diacylamines and heterocycles

Technology Process of N,N-Dimethylacetamide dimethyl acetal

There total 9 articles about N,N-Dimethylacetamide dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

sodium methylate (124-41-4) + N,N-dimethylacetamide-dimethyl sulfate complex (920-98-9) → N,N-dimethylacetamide dimethyl acetal (18871-66-4)

Guidance literature:

In methanol; for 20h; Ambient temperature;

DOI:10.1021/jo00193a045

Reference yield:

methanol (67-56-1) + (1-Methoxy-1-phenylphosphanyl-ethyl)-dimethyl-amine (89865-20-3) → N,N-dimethylacetamide dimethyl acetal (18871-66-4) + phenylphosphane (638-21-1)

Guidance literature:

In acetonitrile;

DOI:10.1016/S0040-4039(00)81820-1

Reference yield:

methanol (67-56-1) + N,N-dimethylamino-P-phenyl-C-methylmethylenephosphine (75589-83-2) → N,N-dimethylacetamide dimethyl acetal (18871-66-4) + (1-Methoxy-1-phenylphosphanyl-ethyl)-dimethyl-amine (89865-20-3) + phenylphosphane (638-21-1)

Guidance literature:

In acetonitrile; Heating;

DOI:10.1016/S0040-4039(00)81820-1

upstream raw materials:

methanol

N,N-dimethylamino-P-phenyl-C-methylmethylenephosphine

(1-Methoxy-1-phenylphosphanyl-ethyl)-dimethyl-amine

sodium methylate

Downstream raw materials:

4-phenyl-2-pyrrolidinylpyrido<2,3-d>pyridazine

4-Phenyl-2-thiomorpholin-4-yl-pyrido[2,3-d]pyridazine

7-(4-ethylpiperazinyl)-5-phenylpyrido<2,3-c>pyridazine

3-Chloro-7-(4-ethyl-piperazin-1-yl)-5-phenyl-pyrido[2,3-c]pyridazine

Refernces

• 1、 Potthast, Antje,Rosenau, Thomas,Sixta, Herbert,Kosma, Paul. "Degradation of cellulosic materials by heating in DMAc/LiCl". . p. 7757 - 7759. Retrieved 2002.
• 2、 Salomon, Robert G.,Raychaudhuri, Swadesh R.. "Convenient Preparation of N,N-Dimethylacetamide Dimethyl Acetal". . p. 3659 - 3660. Retrieved 1984.