Technology Process of 1H-Pyrrole-3-carboxaldehyde,
1-[(3-chlorophenyl)sulfonyl]-4-methyl-5-phenyl-
There total 5 articles about 1H-Pyrrole-3-carboxaldehyde,
1-[(3-chlorophenyl)sulfonyl]-4-methyl-5-phenyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 1-[(3-chlorophenyl)sulfonyl]-4-methyl-5-phenyl-1H-pyrrole-3-carboxylate;
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 0.5h;
With
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide;
In
acetonitrile;
at 0 - 35 ℃;
for 2h;
Molecular sieve;
- Guidance literature:
-
With
hydrogenchloride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide;
silica gel;
In
tetrahydrofuran; ethyl acetate; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil; hexane / -78 - 35 °C
1.2: 35 °C / Cooling with ice
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 0.07 h / 140 °C / Microwave irradiation
3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.5 h / -78 °C
3.2: 2 h / 0 - 35 °C / Molecular sieve
With
tetrakis(triphenylphosphine) palladium(0); sodium hydride; diisobutylaluminium hydride; sodium carbonate;
In
tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; N,N-dimethyl-formamide; toluene; mineral oil;