5-CHLOROPYRAZINE-2-CARBALDEHYDE

Base Information

• Chemical Name: 5-CHLOROPYRAZINE-2-CARBALDEHYDE
• CAS No.: 88625-24-5
• Molecular Formula: C₅H₃ClN₂O
• Molecular Weight: 142.545
• Hs Code.: 2933990090
• Mol file: 88625-24-5.mol

Synonyms:5-chloropyrazine-2-carbaldehyde;

Chemical Property of 5-CHLOROPYRAZINE-2-CARBALDEHYDE

Chemical Property:

• Boiling Point: 221oC
• PKA: -3.78±0.10(Predicted)
• Flash Point: 88oC
• PSA: 42.85000
• Density: 1.432
• LogP: 0.94250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Chloropyrazine-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLOROPYRAZINE-2-CARBALDEHYDE

There total 3 articles about 5-CHLOROPYRAZINE-2-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

methyl 5-chloropyrazine-2-carboxylate (33332-25-1) → 5-chloropyrazine-2-carbaldehyde (88625-24-5)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -55 ℃; for 1h; Inert atmosphere;

Reference yield: 50.7%

(5-chloro-2-pyrazinyl)methanol (72788-94-4) → 5-chloropyrazine-2-carbaldehyde (88625-24-5)

Guidance literature:

With manganese(IV) oxide; In chloroform; for 2h; Reflux;

Reference yield:

5-chloropyrazinoic acid (36070-80-1) → 5-chloropyrazine-2-carbaldehyde (88625-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 2 h / 80 °C

1.2: 2 h / 50 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 °C

With thionyl chloride; diisobutylaluminium hydride; In tetrahydrofuran;

DOI:10.1021/acs.jmedchem.5b00678

upstream raw materials:

methyl 5-chloropyrazine-2-carboxylate

5-chloropyrazinoic acid

(5-chloro-2-pyrazinyl)methanol

Downstream raw materials:

(5-chloro-2-pyrazinyl)methanol

Refernces

• 1、 -. "SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS". . . Retrieved 2018/06/06.
• 2、 -. "CONTINUOUS ARYCYCLIC COMPOUND". Page/Page column 91-92. . Retrieved 2012/06/30.