Pyruvate

Base Information

• Chemical Name: Pyruvate
• CAS No.: 57-60-3
• Molecular Formula: C3H3O3-
• Molecular Weight: 87.055
• UNII: HO43T60JMG
• DSSTox Substance ID: DTXSID50205604
• Nikkaji Number: J469.720K
• Wikidata: Q27089397
• NCI Thesaurus Code: C116012
• Mol file: 57-60-3.mol

Synonyms:Acid, Pyruvic;Pyruvate;Pyruvic Acid

Chemical Property of Pyruvate

Chemical Property:

• Boiling Point: 165°Cat760mmHg
• Flash Point: 54.3°C
• Density: g/cm³
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 87.008218953
• Heavy Atom Count: 6
• Complexity: 78.5

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C(=O)[O-]
• Recent ClinicalTrials: Pilot Study of (MR) Imaging With Pyruvate (13C) to Detect High Grade Prostate Cancer

Technology Process of Pyruvate

There total 19 articles about Pyruvate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

D-glucose (50-99-7) + phosphoenolpyruvic acid (138-08-9) → D-glucose 6-phosphate (56-73-5,3672-15-9,6665-00-5,82259-50-5,89396-13-4,92418-43-4,136376-93-7,136376-97-1,136377-00-9,136377-02-1,136377-04-3,136377-07-6,136377-08-7,136377-11-2,136377-13-4,136377-14-5,136457-25-5) + piruvate (57-60-3)

Guidance literature:

With ammonium sulfate; NAD; pyruvate kinase e; hexokinase; In hexane; water; for 32h; membran-enclosed enzymatic catalysis;

DOI:10.1021/ja00238a067

Reference yield:

trans-benzylidenepyruvate → piruvate (57-60-3) + benzaldehyde (100-52-7)

Guidance literature:

With water; Kinetics;

DOI:10.1021/acs.biochem.9b00652

Reference yield:

NAD (53-84-9,66844-06-2) + (S)-malate dicarboxylate (149-61-1,3343-77-9,3343-78-0,6204-95-1,26374-07-2) → piruvate (57-60-3) + NADH (58-68-4,443892-10-2)

Guidance literature:

With recombinant Arabidopsis thaliana NAD-dependent malic enzyme 2; manganese(ll) chloride; at 30 ℃; pH=6.5; Concentration; Reagent/catalyst; Kinetics; Mechanism; aq. buffer; Enzymatic reaction;

DOI:10.1042/BJ20100497

upstream raw materials:

2-amino-3-chloropropanoic acid

D-glucose

phosphoenolpyruvic acid

L-cystine

Downstream raw materials:

L-tyrosine

carbon dioxide

acetaldehyde

N-Acetylneuraminic acid

Refernces

• 1、 Ukai, Koji,Sekiya, Jiro. "Purification and Characterization of Cystine Lyase a from Broccoli Inflorescence". . p. 1890 - 1895. Retrieved 1997.
• 2、 Mydy, Lisa S.,Hoppe, Robert W.,Hagemann, Trevor M.,Schwabacher, Alan W.,Silvaggi, Nicholas R.. "Mechanistic Studies of the Streptomyces bingchenggensis Aldolase-Dehydratase: Implications for Substrate and Reaction Specificity in the Acetoacetate Decarboxylase-like Superfamily". . p. 4136 - 4147. Retrieved 2019/10/11.
• 3、 Plach, Maximilian G.,L?ffler, Patrick,Merkl, Rainer,Sterner, Reinhard. "Conversion of Anthranilate Synthase into Isochorismate Synthase: Implications for the Evolution of Chorismate-Utilizing Enzymes". supporting information. p. 11270 - 11274. Retrieved 2016/07/06.