Ethanamine, 2-(2-methylphenoxy)-

Base Information

• Chemical Name: Ethanamine, 2-(2-methylphenoxy)-
• CAS No.: 26583-60-8
• Molecular Formula: C9H13 N O
• Molecular Weight: 151.208
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID4067226
• Nikkaji Number: J422.186I
• Wikidata: Q81993806
• Mol file: 26583-60-8.mol

Synonyms:2-(2-methylphenoxy)ethylamine;26583-60-8;2-(2-methylphenoxy)ethanamine;Ethanamine, 2-(2-methylphenoxy)-;2-(o-Tolyloxy)ethanamine;2-o-Tolyloxy-ethylamine;Ethanolamine cresylate;MFCD02598962;1-(2-aminoethoxy)-2-methylbenzene;SCHEMBL3528979;DTXSID4067226;2-(2-methyl-phenoxy)-ethylamine;2-(2-methylphenoxy)-1-ethanamine;2-(2-methylphenoxy)ethan-1-amine;AMY20097;STK523737;AKOS000112561;SB76383;NCGC00339249-01;AS-31725;SY008284;2-(2-Methylphenoxy)ethanamine, AldrichCPR;CS-0152945;FT-0732205;EN300-58795;AB01331716-02;A877182;AE-641/00657056;(R)-N-(4-(1-aminoethyl)phenyl)-6-(pyridin-4-yl)quinazolin-2-amine

Chemical Property of Ethanamine, 2-(2-methylphenoxy)-

Chemical Property:

• Vapor Pressure: 0.0279mmHg at 25°C
• Boiling Point: 246°Cat760mmHg
• PKA: 8.53±0.10(Predicted)
• Flash Point: 103.9°C
• PSA: 35.25000
• Density: 1.008g/cm³
• LogP: 2.03280
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 106

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Methylphenoxy)ethanamine Aldrich ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1OCCN

Technology Process of Ethanamine, 2-(2-methylphenoxy)-

There total 6 articles about Ethanamine, 2-(2-methylphenoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ortho-cresol (95-48-7,77504-84-8) → β-(2-methylphenoxy)ethylamine (26583-60-8)

Guidance literature:

With sodium hydroxide; In hexane; ethyl acetate; ethylene dibromide;

Reference yield:

N-(2-o-tolyloxy-ethyl)-phthalimide → β-(2-methylphenoxy)ethylamine (26583-60-8)

Guidance literature:

With hydrazine hydrate; In ethanol; at 50 ℃; for 4h;

DOI:10.1021/acsmedchemlett.6b00330

Reference yield:

1-(2-bromoethoxy)-2-methylbenzene (18800-32-3) → β-(2-methylphenoxy)ethylamine (26583-60-8)

Guidance literature:

With ammonia; at 120 ℃;

upstream raw materials:

1-(2-bromoethoxy)-2-methylbenzene

ortho-cresol

ortho-methylphenoxyacetamide

Downstream raw materials:

2-phenyl-3-(2-o-tolyloxy-ethyl)-thiazolidin-4-one

2-(2,4-dichloro-phenyl)-3-(2-o-tolyloxy-ethyl)-thiazolidin-4-one

Refernces

• 1、 Bednarski, Marek,Otto, Monika,Dudek, Magdalena,Ko?aczkowski, Marcin,Bucki, Adam,Siwek, Agata,Groszek, Gra?yna,Maziarz, El?bieta,Wilk, Piotr,Sapa, Jacek. "Synthesis and pharmacological activity of a new series of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)-propan-2-ol analogs". . p. 211 - 223. Retrieved 2018/05/08.
• 2、 Franchini, Silvia,Prandi, Adolfo,Sorbi, Claudia,Tait, Annalisa,Baraldi, Annamaria,Angeli, Piero,Buccioni, Michela,Cilia, Antonio,Poggesi, Elena,Fossa, Paola,Brasili, Livio. "Discovery of a new series of 5-HT1A receptor agonists". scheme or table. p. 2017 - 2020. Retrieved 2010/07/07.