1-Piperidinecarboxamide

Base Information

• Chemical Name: 1-Piperidinecarboxamide
• CAS No.: 2158-03-4
• Molecular Formula: C6H12 N2 O
• Molecular Weight: 128.174
• Hs Code.: 2933399090
• European Community (EC) Number: 218-476-5
• NSC Number: 108219
• UNII: 5B92J0WM0S
• DSSTox Substance ID: DTXSID4062220
• Nikkaji Number: J299.125J
• Wikidata: Q81989916
• Mol file: 2158-03-4.mol

Synonyms:piperidine-1-carboxamide;1-Piperidinecarboxamide;2158-03-4;1-carbamoylpiperidine;Piperidine-N-carbonic acid amide;N,N-Pentamethyleneurea;5B92J0WM0S;EINECS 218-476-5;NSC 108219;NSC-108219;BRN 0112517;1-Carbamylpiperidine;piperidine amide;NSC108219;N-CARBAMOYLPIPERIDINE;SCHEMBL5457;piperidine-1-carbimidic acid;UNII-5B92J0WM0S;1-Piperidinecarboxamide, 99%;PIPERIDINE-N-CARBOXAMIDE;DTXSID4062220;SCHEMBL10517622;CAA15803;AKOS000200494;PIPERIDINE, 1-(AMINOCARBONYL)-;LS-114497;EN300-06077;A911388;AL-398/25017069;J-014155;Z56917364

Chemical Property of 1-Piperidinecarboxamide

Chemical Property:

• Vapor Pressure: 0.0783mmHg at 25°C
• Melting Point: 104-106 °C(lit.)
• Refractive Index: 1.4880 (estimate)
• Boiling Point: 227.3°Cat760mmHg
• Flash Point: 91.2°C
• PSA: 46.33000
• Density: 1.105g/cm³
• LogP: 1.18920
• Storage Temp.: 2-8°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 128.094963011
• Heavy Atom Count: 9
• Complexity: 108

Purity/Quality:

98%,99%, ^*data from raw suppliers

Piperidine-1-carboxamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CCN(CC1)C(=O)N

Technology Process of 1-Piperidinecarboxamide

There total 28 articles about 1-Piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

piperidine (110-89-4) + 2-propenamide (79-06-1,12624-24-7,25038-45-3,27754-57-0,33338-03-3,39387-77-4,68247-81-4,9082-06-8,79079-15-5) → 1-piperidinecarboxamide (2158-03-4)

Guidance literature:

With Iron(III) nitrate nonahydrate; In toluene; for 12h; Reflux;

DOI:10.1021/jo500562w

Reference yield: 91.0%

1-piperidinylcarbonnitrile (1530-87-6) → 1-piperidinecarboxamide (2158-03-4)

Guidance literature:

With [OsCl₂(η⁶-p-cymene)(PMe₂OH)]; water; at 40 ℃; for 1.5h; Reagent/catalyst; Inert atmosphere; Sealed tube;

DOI:10.1039/d0cy00523a

Reference yield: 88.6%

piperidine (110-89-4) + urea (57-13-6) → 1-piperidinecarboxamide (2158-03-4)

Guidance literature:

at 120 ℃; for 6h; Inert atmosphere;

upstream raw materials:

piperidine

ethyl acetylcarbamate

urea

potassium cyanate

Downstream raw materials:

N-(2-fluorobenzoyl)piperidine-1-carboxamide

N-(4-cyanobenzoyl)piperidine-1-carboxamide

6-cyano-N-(piperidine-1-carbonyl)nicotinamide

N-Benzoyl-N',N'-pentamethylen-harnstoff

Refernces

• 1、 álvarez, Daniel,Cadierno, Victorio,Crochet, Pascale,González-Fernández, Rebeca,López, Ramón,Menéndez, M. Isabel. "Catalytic hydration of cyanamides with phosphinous acid-based ruthenium(ii) and osmium(ii) complexes: scope and mechanistic insights". . p. 4084 - 4098. Retrieved 2020/07/09.
• 2、 Christian, Alec H.,Jia, Shang,Cao, Wendy,Zhang, Patricia,Meza, Arismel Tena,Sigman, Matthew S.,Chang, Christopher J.,Toste, F. Dean. "A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation". . p. 12657 - 12662. Retrieved 2019/09/04.